Flat adenomas in a colon cancer-prone kindred

Henry T. Lynch, Tom Smyrk, Stephen J. Lanspa, Joseph N. Marcus, Mary Kriegler, Jane F. Lynch, Henry D. Appelman

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Abstract

We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278-282].

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalJournal of the National Cancer Institute
Volume80
Issue number4
DOIs
StatePublished - Apr 20 1988

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lynch, H. T., Smyrk, T., Lanspa, S. J., Marcus, J. N., Kriegler, M., Lynch, J. F., & Appelman, H. D. (1988). Flat adenomas in a colon cancer-prone kindred. Journal of the National Cancer Institute, 80(4), 278-282. https://doi.org/10.1093/jnci/80.4.278