Flat adenomas in a colon cancer-prone kindred

Henry T. Lynch, Tom Smyrk, Stephen J. Lanspa, Joseph N. Marcus, Mary Kriegler, Jane F. Lynch, Henry D. Appelman

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278-282].

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalJournal of the National Cancer Institute
Volume80
Issue number4
DOIs
StatePublished - Apr 20 1988

Fingerprint

Colorectal Cancer
Adenoma
Colonic Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Cancer
Phenotype
Subset
Term
Family
Colorectal cancer
Neoplasms

All Science Journal Classification (ASJC) codes

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Cancer Research

Cite this

Lynch, H. T., Smyrk, T., Lanspa, S. J., Marcus, J. N., Kriegler, M., Lynch, J. F., & Appelman, H. D. (1988). Flat adenomas in a colon cancer-prone kindred. Journal of the National Cancer Institute, 80(4), 278-282. https://doi.org/10.1093/jnci/80.4.278

Flat adenomas in a colon cancer-prone kindred. / Lynch, Henry T.; Smyrk, Tom; Lanspa, Stephen J.; Marcus, Joseph N.; Kriegler, Mary; Lynch, Jane F.; Appelman, Henry D.

In: Journal of the National Cancer Institute, Vol. 80, No. 4, 20.04.1988, p. 278-282.

Research output: Contribution to journalArticle

Lynch, HT, Smyrk, T, Lanspa, SJ, Marcus, JN, Kriegler, M, Lynch, JF & Appelman, HD 1988, 'Flat adenomas in a colon cancer-prone kindred', Journal of the National Cancer Institute, vol. 80, no. 4, pp. 278-282. https://doi.org/10.1093/jnci/80.4.278
Lynch, Henry T. ; Smyrk, Tom ; Lanspa, Stephen J. ; Marcus, Joseph N. ; Kriegler, Mary ; Lynch, Jane F. ; Appelman, Henry D. / Flat adenomas in a colon cancer-prone kindred. In: Journal of the National Cancer Institute. 1988 ; Vol. 80, No. 4. pp. 278-282.
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