Flt3 ligand: A novel cytokine prevents allergic asthma in a mouse model

Devendra K. Agrawal, Michael T. Hopfenspirger, Jennifer Chavez, James E. Talmadge

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations

    Abstract

    Flt-3 ligand (FL), a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Since type 2 T cells predominate in asthma and IL-12 prevents the differentiation of naive T lymphocytes to a type 2 phenotype, we hypothesized that FL could prevent the development of asthma-like conditions in the ovalbumin mouse model. We found that co-administration of FL during ovalbumin sensitization abrogated late allergic responses, but had no effect on early allergic responses. Airway hyperresponsiveness to methacholine was also blocked by FL treatment. Analysis of bronchoalveolar lavage (BAL) fluid demonstrated a significant reduction in eosinophils, with concomitant decreases in IL-5 and increases in IFN-γ levels. However, there was no change in BAL fluid IL-4 and serum IgE levels. These data suggest that FL treatment prevents ovalbumin-induced asthma in the mouse and may provide a useful adjuvant in the treatment of human asthma.

    Original languageEnglish
    Pages (from-to)2081-2089
    Number of pages9
    JournalInternational Immunopharmacology
    Volume1
    Issue number12
    DOIs
    StatePublished - 2001

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Pharmacology

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