Abstract
The purpose of this study was to determine gastrointestinal (GI) permeability during prolonged treadmill running (60 min at 70% V̇O 2max) with and without fluid intake (3 ml/kg body mass/10 min). Twenty runners (11 males, 9 females; age = 22 ± 3 (SD) yrs; mean V̇O2max = 55.7 ± 5.0 ml/kg/min) completed four experiments: 1) rest, 2) running with no fluid (NF), 3) running with ingestion of a 4% glucose solution (GLU), and 4) running with ingestion of a water placebo (PLA). To determine GI permeability, subjects also drank a solution containing 5 g sucrose (S), 5 g lactulose (L), and 2 g rhamnose (R) immediately prior to each trial. Gastroduodenal permeability was determined by urinary S excretion, while small intestinal permeability was determined by the L/R excretion ratio. Percent body mass loss (i.e., dehydration) was negligible during rest, GLU and PLA, while NF resulted in a 1.5% loss of body mass (p <0.05). Gastroduodenal and intestinal permeability were significantly (p <0.008) increased in NF compared to rest. There were no other differences in GI permeability. These results indicate that fluid restriction during 1 h of steady-state running increases GI permeability above resting levels.
| Original language | English |
|---|---|
| Pages (from-to) | 194-198 |
| Number of pages | 5 |
| Journal | International Journal of Sports Medicine |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2008 |
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All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Fluid restriction during running increases GI permeability. / Lambert, G. Patrick; Lang, J.; Bull, A.; Pfeifer, P. C.; Eckerson, Joan; Moore, C.; Lanspa, Stephen J.; O'Brien, J.
In: International Journal of Sports Medicine, Vol. 29, No. 3, 03.2008, p. 194-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluid restriction during running increases GI permeability
AU - Lambert, G. Patrick
AU - Lang, J.
AU - Bull, A.
AU - Pfeifer, P. C.
AU - Eckerson, Joan
AU - Moore, C.
AU - Lanspa, Stephen J.
AU - O'Brien, J.
PY - 2008/3
Y1 - 2008/3
N2 - The purpose of this study was to determine gastrointestinal (GI) permeability during prolonged treadmill running (60 min at 70% V̇O 2max) with and without fluid intake (3 ml/kg body mass/10 min). Twenty runners (11 males, 9 females; age = 22 ± 3 (SD) yrs; mean V̇O2max = 55.7 ± 5.0 ml/kg/min) completed four experiments: 1) rest, 2) running with no fluid (NF), 3) running with ingestion of a 4% glucose solution (GLU), and 4) running with ingestion of a water placebo (PLA). To determine GI permeability, subjects also drank a solution containing 5 g sucrose (S), 5 g lactulose (L), and 2 g rhamnose (R) immediately prior to each trial. Gastroduodenal permeability was determined by urinary S excretion, while small intestinal permeability was determined by the L/R excretion ratio. Percent body mass loss (i.e., dehydration) was negligible during rest, GLU and PLA, while NF resulted in a 1.5% loss of body mass (p <0.05). Gastroduodenal and intestinal permeability were significantly (p <0.008) increased in NF compared to rest. There were no other differences in GI permeability. These results indicate that fluid restriction during 1 h of steady-state running increases GI permeability above resting levels.
AB - The purpose of this study was to determine gastrointestinal (GI) permeability during prolonged treadmill running (60 min at 70% V̇O 2max) with and without fluid intake (3 ml/kg body mass/10 min). Twenty runners (11 males, 9 females; age = 22 ± 3 (SD) yrs; mean V̇O2max = 55.7 ± 5.0 ml/kg/min) completed four experiments: 1) rest, 2) running with no fluid (NF), 3) running with ingestion of a 4% glucose solution (GLU), and 4) running with ingestion of a water placebo (PLA). To determine GI permeability, subjects also drank a solution containing 5 g sucrose (S), 5 g lactulose (L), and 2 g rhamnose (R) immediately prior to each trial. Gastroduodenal permeability was determined by urinary S excretion, while small intestinal permeability was determined by the L/R excretion ratio. Percent body mass loss (i.e., dehydration) was negligible during rest, GLU and PLA, while NF resulted in a 1.5% loss of body mass (p <0.05). Gastroduodenal and intestinal permeability were significantly (p <0.008) increased in NF compared to rest. There were no other differences in GI permeability. These results indicate that fluid restriction during 1 h of steady-state running increases GI permeability above resting levels.
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UR - http://www.scopus.com/inward/citedby.url?scp=40649116445&partnerID=8YFLogxK
U2 - 10.1055/s-2007-965163
DO - 10.1055/s-2007-965163
M3 - Article
C2 - 17614027
AN - SCOPUS:40649116445
VL - 29
SP - 194
EP - 198
JO - International Journal of Sports Medicine
JF - International Journal of Sports Medicine
SN - 0172-4622
IS - 3
ER -