TY - JOUR
T1 - Fluoroquinolones and the risk of aortopathy
T2 - A systematic review and meta-analysis
AU - Latif, Azka
AU - Ahsan, Muhammad Junaid
AU - Kapoor, Vikas
AU - Lateef, Noman
AU - Malik, Saad Ullah
AU - Patel, Apurva D.
AU - Khan, Behram Ahmed
AU - Bittner, Marvin
AU - Holmberg, Mark
N1 - Publisher Copyright:
© 2020 Board of Regents of the University of Wisconsin System and The Medical College of Wisconsin, Inc.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Introduction: Recent studies have raised concerns that fluoroquinolone use is associated with an increased risk of aortopathy, including aortic aneurysm with and without dissection. Objective: We performed a meta-analysis with a comprehensive literature review to further investigate this association. Methods: This analysis was conducted per PRISMA guidelines. PubMed, Cochrane Library, ClinicalTrials.gov, Embase, Web of Science, and Google Scholar were searched for studies that included adult patients (age >18 years) exposed to fluoroquinolones or control antibiotics (amoxicillin/any other antibiotic) for urinary tract infection or pneumonia with a primary outcome of aortic aneurysm or dissection. Heterogeneity was calculated using Q statistic I2. Results: A total of 6 studies—comprised of 59% males—were included in our analysis, which showed an increased combined risk of development of aortic aneurysm and aortic dissection with quinolone exposure when compared with controls (relative risk [RR] = 2.11; 95% CI, 1.62-2.75; I2 = 83.700). Individual relative risk for aortic aneurysm (RR = 2.83; 95% CI, 2.02-3.95, I2 = 89.150) and aortic dissection (RR = 1.99; 95% CI, 1.23-3.06; I2 = 71.33) also were significantly increased. Conclusion: Compared to other antibiotics, the use of fluoroquinolones was associated with a significantly higher risk of aortic aneurysm and dissection combined.
AB - Introduction: Recent studies have raised concerns that fluoroquinolone use is associated with an increased risk of aortopathy, including aortic aneurysm with and without dissection. Objective: We performed a meta-analysis with a comprehensive literature review to further investigate this association. Methods: This analysis was conducted per PRISMA guidelines. PubMed, Cochrane Library, ClinicalTrials.gov, Embase, Web of Science, and Google Scholar were searched for studies that included adult patients (age >18 years) exposed to fluoroquinolones or control antibiotics (amoxicillin/any other antibiotic) for urinary tract infection or pneumonia with a primary outcome of aortic aneurysm or dissection. Heterogeneity was calculated using Q statistic I2. Results: A total of 6 studies—comprised of 59% males—were included in our analysis, which showed an increased combined risk of development of aortic aneurysm and aortic dissection with quinolone exposure when compared with controls (relative risk [RR] = 2.11; 95% CI, 1.62-2.75; I2 = 83.700). Individual relative risk for aortic aneurysm (RR = 2.83; 95% CI, 2.02-3.95, I2 = 89.150) and aortic dissection (RR = 1.99; 95% CI, 1.23-3.06; I2 = 71.33) also were significantly increased. Conclusion: Compared to other antibiotics, the use of fluoroquinolones was associated with a significantly higher risk of aortic aneurysm and dissection combined.
UR - http://www.scopus.com/inward/record.url?scp=85094159915&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094159915&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2018.09.067
DO - 10.1016/j.ijcard.2018.09.067
M3 - Review article
C2 - 33091293
AN - SCOPUS:85094159915
VL - 119
SP - 185
EP - 189
JO - Wisconsin Medical Journal
JF - Wisconsin Medical Journal
SN - 0043-6542
IS - 3
ER -