Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis

Azka Latif, Muhammad Junaid Ahsan, Vikas Kapoor, Noman Lateef, Saad Ullah Malik, Apurva D. Patel, Behram Ahmed Khan, Marvin Bittner, Mark Holmberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Recent studies have raised concerns that fluoroquinolone use is associated with an increased risk of aortopathy, including aortic aneurysm with and without dissection. Objective: We performed a meta-analysis with a comprehensive literature review to further investigate this association. Methods: This analysis was conducted per PRISMA guidelines. PubMed, Cochrane Library, ClinicalTrials.gov, Embase, Web of Science, and Google Scholar were searched for studies that included adult patients (age >18 years) exposed to fluoroquinolones or control antibiotics (amoxicillin/any other antibiotic) for urinary tract infection or pneumonia with a primary outcome of aortic aneurysm or dissection. Heterogeneity was calculated using Q statistic I2. Results: A total of 6 studies—comprised of 59% males—were included in our analysis, which showed an increased combined risk of development of aortic aneurysm and aortic dissection with quinolone exposure when compared with controls (relative risk [RR] = 2.11; 95% CI, 1.62-2.75; I2 = 83.700). Individual relative risk for aortic aneurysm (RR = 2.83; 95% CI, 2.02-3.95, I2 = 89.150) and aortic dissection (RR = 1.99; 95% CI, 1.23-3.06; I2 = 71.33) also were significantly increased. Conclusion: Compared to other antibiotics, the use of fluoroquinolones was associated with a significantly higher risk of aortic aneurysm and dissection combined.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalWisconsin Medical Journal
Volume119
Issue number3
DOIs
StatePublished - Sep 2020

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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