Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity

Ying Ruan, Mary H. Peterson, Eric M. Wauson, Janee Gelineau Van Waes, Richard H. Finnell, Roseann L. Vorce

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

It has been proposed that arsenic exerts its toxic effects, in part, by perturbing cellular methyl metabolism. Based on the hypothesis that folic acid treatment will attenuate the cytotoxic and growth inhibitory effects of arsenic, SWV/Fnn embryo fibroblasts were cultured in media supplemented with various concentrations of folic acid during treatment with sodium arsenite or dimethylarsinic acid (DMA). It was found that folic acid protects SWV/Fnn embryo fibroblasts from sodium arsenite and DMA cytotoxicity in a dose-dependent manner. In contrast, folic acid supplementation has no effect on toxicity resulting from treatment with ethanol or staurosporine, suggesting that folic acid is not generally protective against necrosis and apoptosis. Although folic acid protects against acute arsenic toxicity, this agent shows a modest and delayed ability to attenuate the growth inhibitory effect of arsenic on these cells. These results support a model in which perturbations of methyl metabolism contribute to the acute cytotoxicity of arsenic. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)129-137
Number of pages9
JournalToxicology Letters
Volume117
Issue number3
DOIs
StatePublished - Nov 20 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Toxicology

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    Ruan, Y., Peterson, M. H., Wauson, E. M., Waes, J. G. V., Finnell, R. H., & Vorce, R. L. (2000). Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity. Toxicology Letters, 117(3), 129-137. https://doi.org/10.1016/S0378-4274(00)00254-X