FREQUENCY OF OSTEOMALACIA AND OSTEOPOROSIS IN FRACTURES OF THE PROXIMAL FEMUR

J. E. Aaron; L. Stasiak; J. C. Gallagher; E. B. Longton; M. Nicholson; J. Anderson; B. E.C. Nordin

doi:10.1016/S0140-6736(74)92545-8

FREQUENCY OF OSTEOMALACIA AND OSTEOPOROSIS IN FRACTURES OF THE PROXIMAL FEMUR

J. E. Aaron, L. Stasiak, J. C. Gallagher, E. B. Longton, M. Nicholson, J. Anderson, B. E.C. Nordin

Department of Medicine

Research output: Contribution to journal › Article

198 Scopus citations

Abstract

A quantitative histological examination was made of iliac-crest biopsy specimens obtained from 125 cases of fracture of the proximal femur (102 women and 23 men). 35 women (34%) demonstrated a more severe degree of osteoporosis than would be expected for their age and 35 (including 10 of those with osteoporosis) had some evidence of osteomalacia. There was some evidence of osteomalacia in 11 (47%) men. 5 women and 2 men with osteomalacia had previously undergone partial gastrectomy. It is suggested that osteomalacia in the elderly makes an important contribution to the steep rise in femoral-neck fractures with advancing age in the U.K. and that this is attributable to an absolute or relative deficiency of vitamin D. It is also suggested that at least some of the osteoporotic component may also be attributable to a degree of vitamin-D deficiency sufficient to cause malabsorption of calcium but not sufficient to produce osteomalacia.

Original language	English (US)
Pages (from-to)	229-233
Number of pages	5
Journal	The Lancet
Volume	303
Issue number	7851
DOIs	https://doi.org/10.1016/S0140-6736(74)92545-8
State	Published - Feb 16 1974

All Science Journal Classification (ASJC) codes

Medicine(all)

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Aaron, J. E., Stasiak, L., Gallagher, J. C., Longton, E. B., Nicholson, M., Anderson, J., & Nordin, B. E. C. (1974). FREQUENCY OF OSTEOMALACIA AND OSTEOPOROSIS IN FRACTURES OF THE PROXIMAL FEMUR. The Lancet, 303(7851), 229-233. https://doi.org/10.1016/S0140-6736(74)92545-8

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abstract = "A quantitative histological examination was made of iliac-crest biopsy specimens obtained from 125 cases of fracture of the proximal femur (102 women and 23 men). 35 women (34%) demonstrated a more severe degree of osteoporosis than would be expected for their age and 35 (including 10 of those with osteoporosis) had some evidence of osteomalacia. There was some evidence of osteomalacia in 11 (47%) men. 5 women and 2 men with osteomalacia had previously undergone partial gastrectomy. It is suggested that osteomalacia in the elderly makes an important contribution to the steep rise in femoral-neck fractures with advancing age in the U.K. and that this is attributable to an absolute or relative deficiency of vitamin D. It is also suggested that at least some of the osteoporotic component may also be attributable to a degree of vitamin-D deficiency sufficient to cause malabsorption of calcium but not sufficient to produce osteomalacia.",

author = "Aaron, {J. E.} and L. Stasiak and Gallagher, {J. C.} and Longton, {E. B.} and M. Nicholson and J. Anderson and Nordin, {B. E.C.}",

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AU - Aaron, J. E.

AU - Stasiak, L.

AU - Gallagher, J. C.

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AU - Nicholson, M.

AU - Anderson, J.

AU - Nordin, B. E.C.

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N2 - A quantitative histological examination was made of iliac-crest biopsy specimens obtained from 125 cases of fracture of the proximal femur (102 women and 23 men). 35 women (34%) demonstrated a more severe degree of osteoporosis than would be expected for their age and 35 (including 10 of those with osteoporosis) had some evidence of osteomalacia. There was some evidence of osteomalacia in 11 (47%) men. 5 women and 2 men with osteomalacia had previously undergone partial gastrectomy. It is suggested that osteomalacia in the elderly makes an important contribution to the steep rise in femoral-neck fractures with advancing age in the U.K. and that this is attributable to an absolute or relative deficiency of vitamin D. It is also suggested that at least some of the osteoporotic component may also be attributable to a degree of vitamin-D deficiency sufficient to cause malabsorption of calcium but not sufficient to produce osteomalacia.

AB - A quantitative histological examination was made of iliac-crest biopsy specimens obtained from 125 cases of fracture of the proximal femur (102 women and 23 men). 35 women (34%) demonstrated a more severe degree of osteoporosis than would be expected for their age and 35 (including 10 of those with osteoporosis) had some evidence of osteomalacia. There was some evidence of osteomalacia in 11 (47%) men. 5 women and 2 men with osteomalacia had previously undergone partial gastrectomy. It is suggested that osteomalacia in the elderly makes an important contribution to the steep rise in femoral-neck fractures with advancing age in the U.K. and that this is attributable to an absolute or relative deficiency of vitamin D. It is also suggested that at least some of the osteoporotic component may also be attributable to a degree of vitamin-D deficiency sufficient to cause malabsorption of calcium but not sufficient to produce osteomalacia.

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