Fumonisin B1 induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet

Kenneth A. Voss, Ronald T. Riley, Janee Gelineau-van Waes

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Scope: Fumonisin B1 (FB1) is found in corn-based foods and is a possible risk factor for neural tube defects (NTDs). The mechanism(s) underlying NTD induction by FB1 in LM/Bc mice is not understood; however, evidence suggests disrupted folate transport is involved. Methods and results: Female LM/Bc mice were fed folate-sufficient (control) or folate-deficient diet beginning 5 wk before mating, treated with 0 (vehicle), 2.5 or 10 mg/kg FB1 by intraperitoneal injection on embryonic days 7 (E7) and E8, and their fetuses examined on E16. Dose-dependent NTD induction was found in groups fed the control diet: 3 of 13 low-dose and 10 of 11 high-dose litters were affected. Among groups fed folate-deficient diet, NTDs were found only in 4 of 11 high-dose litters. In another trial, consumption of folate-deficient diet also resulted in fewer NTDs at a dose of 10 mg/kg FB1 and reduced maternal red blood cell folate levels by 80%. In utero death did not fully account for the differences in NTD rates. Conclusion: Folate deficiency does not exacerbate NTD induction by FB1 in LM/Bc mice. Interactions between folate, other nutritional factors, and FB1 in this mouse model for NTDs are complex and require further investigation.

Original languageEnglish
Pages (from-to)1190-1198
Number of pages9
JournalMolecular Nutrition and Food Research
Volume58
Issue number6
DOIs
StatePublished - 2014

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neural tube defects
fumonisin B1
Neural Tube Defects
Folic Acid
folic acid
Diet
mice
diet
dosage
intraperitoneal injection
Intraperitoneal Injections
Zea mays
fetus
Fetus
erythrocytes
risk factors
Erythrocytes
animal models
Mothers
death

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biotechnology
  • Medicine(all)

Cite this

Fumonisin B1 induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet. / Voss, Kenneth A.; Riley, Ronald T.; Gelineau-van Waes, Janee.

In: Molecular Nutrition and Food Research, Vol. 58, No. 6, 2014, p. 1190-1198.

Research output: Contribution to journalArticle

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