Abstract
Fumonisins are a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly Fusarium moniliforme), a common fungal contaminant of maize. Fumonisins inhibit ceramide synthase, causing accumulation of bioactive intermediates of sphingolipid metabolism (sphinganine and other sphingoid bases and derivatives) as well as depletion of complex sphingolipids, which interferes with the function of some membrane proteins, including the folate-binding protein (human folate receptor α). Fumonisin causes neural tube and craniofacial defects in mouse embryos in culture. Many of these effects are prevented by supplemental folic acid. Recent studies in LMBc mice found that fumonisin exposure in utero increases the frequency of developmental defects and administration of folate or a complex sphingolipid is preventive. High incidences of neural tube defects (NTD) occur in some regions of the world where substantial consumption of fumonisins has been documented or plausibly suggested (Guatemala, South Africa, and China); furthermore, a recent study of NTD in border counties of Texas found a significant association between NTD and consumption of tortillas during the first trimester. Hence, we propose that fumonisins are potential risk factors for NTD, craniofacial anomalies, and other birth defects arising from neural crest cells because of their apparent interference with folate utilization.
| Original language | English |
|---|---|
| Pages (from-to) | 711-716 |
| Number of pages | 6 |
| Journal | Journal of Nutrition |
| Volume | 134 |
| Issue number | 4 |
| State | Published - Apr 2004 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Food Science
Cite this
Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo : A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize. / Marasas, Walter F O; Riley, Ronald T.; Hendricks, Katherine A.; Stevens, Victoria L.; Sadler, Thomas W.; Gelineau-van Waes, Janee; Missmer, Stacey A.; Cabrera, Julio; Torres, Olga; Gelderblom, Wentzel C A; Allegood, Jeremy; Martínez, Carolina; Maddox, Joyce; Miller, J. David; Starr, Lois; Sullards, M. Cameron; Roman, Ana Victoria; Voss, Kenneth A.; Wang, Elaine; Merrill, Alfred H.
In: Journal of Nutrition, Vol. 134, No. 4, 04.2004, p. 711-716.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo
T2 - A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize
AU - Marasas, Walter F O
AU - Riley, Ronald T.
AU - Hendricks, Katherine A.
AU - Stevens, Victoria L.
AU - Sadler, Thomas W.
AU - Gelineau-van Waes, Janee
AU - Missmer, Stacey A.
AU - Cabrera, Julio
AU - Torres, Olga
AU - Gelderblom, Wentzel C A
AU - Allegood, Jeremy
AU - Martínez, Carolina
AU - Maddox, Joyce
AU - Miller, J. David
AU - Starr, Lois
AU - Sullards, M. Cameron
AU - Roman, Ana Victoria
AU - Voss, Kenneth A.
AU - Wang, Elaine
AU - Merrill, Alfred H.
PY - 2004/4
Y1 - 2004/4
N2 - Fumonisins are a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly Fusarium moniliforme), a common fungal contaminant of maize. Fumonisins inhibit ceramide synthase, causing accumulation of bioactive intermediates of sphingolipid metabolism (sphinganine and other sphingoid bases and derivatives) as well as depletion of complex sphingolipids, which interferes with the function of some membrane proteins, including the folate-binding protein (human folate receptor α). Fumonisin causes neural tube and craniofacial defects in mouse embryos in culture. Many of these effects are prevented by supplemental folic acid. Recent studies in LMBc mice found that fumonisin exposure in utero increases the frequency of developmental defects and administration of folate or a complex sphingolipid is preventive. High incidences of neural tube defects (NTD) occur in some regions of the world where substantial consumption of fumonisins has been documented or plausibly suggested (Guatemala, South Africa, and China); furthermore, a recent study of NTD in border counties of Texas found a significant association between NTD and consumption of tortillas during the first trimester. Hence, we propose that fumonisins are potential risk factors for NTD, craniofacial anomalies, and other birth defects arising from neural crest cells because of their apparent interference with folate utilization.
AB - Fumonisins are a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly Fusarium moniliforme), a common fungal contaminant of maize. Fumonisins inhibit ceramide synthase, causing accumulation of bioactive intermediates of sphingolipid metabolism (sphinganine and other sphingoid bases and derivatives) as well as depletion of complex sphingolipids, which interferes with the function of some membrane proteins, including the folate-binding protein (human folate receptor α). Fumonisin causes neural tube and craniofacial defects in mouse embryos in culture. Many of these effects are prevented by supplemental folic acid. Recent studies in LMBc mice found that fumonisin exposure in utero increases the frequency of developmental defects and administration of folate or a complex sphingolipid is preventive. High incidences of neural tube defects (NTD) occur in some regions of the world where substantial consumption of fumonisins has been documented or plausibly suggested (Guatemala, South Africa, and China); furthermore, a recent study of NTD in border counties of Texas found a significant association between NTD and consumption of tortillas during the first trimester. Hence, we propose that fumonisins are potential risk factors for NTD, craniofacial anomalies, and other birth defects arising from neural crest cells because of their apparent interference with folate utilization.
UR - http://www.scopus.com/inward/record.url?scp=11144357212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144357212&partnerID=8YFLogxK
M3 - Review article
C2 - 15051815
AN - SCOPUS:11144357212
VL - 134
SP - 711
EP - 716
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 4
ER -