Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo: A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize

Walter F O Marasas, Ronald T. Riley, Katherine A. Hendricks, Victoria L. Stevens, Thomas W. Sadler, Janee Gelineau-van Waes, Stacey A. Missmer, Julio Cabrera, Olga Torres, Wentzel C A Gelderblom, Jeremy Allegood, Carolina Martínez, Joyce Maddox, J. David Miller, Lois Starr, M. Cameron Sullards, Ana Victoria Roman, Kenneth A. Voss, Elaine Wang, Alfred H. Merrill

Research output: Contribution to journalReview article

381 Citations (Scopus)

Abstract

Fumonisins are a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly Fusarium moniliforme), a common fungal contaminant of maize. Fumonisins inhibit ceramide synthase, causing accumulation of bioactive intermediates of sphingolipid metabolism (sphinganine and other sphingoid bases and derivatives) as well as depletion of complex sphingolipids, which interferes with the function of some membrane proteins, including the folate-binding protein (human folate receptor α). Fumonisin causes neural tube and craniofacial defects in mouse embryos in culture. Many of these effects are prevented by supplemental folic acid. Recent studies in LMBc mice found that fumonisin exposure in utero increases the frequency of developmental defects and administration of folate or a complex sphingolipid is preventive. High incidences of neural tube defects (NTD) occur in some regions of the world where substantial consumption of fumonisins has been documented or plausibly suggested (Guatemala, South Africa, and China); furthermore, a recent study of NTD in border counties of Texas found a significant association between NTD and consumption of tortillas during the first trimester. Hence, we propose that fumonisins are potential risk factors for NTD, craniofacial anomalies, and other birth defects arising from neural crest cells because of their apparent interference with folate utilization.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalJournal of Nutrition
Volume134
Issue number4
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Fumonisins
neural tube defects
sphingolipids
Sphingolipids
Neural Tube
Neural Tube Defects
embryo culture
fumonisins
Folic Acid
folic acid
Zea mays
Embryonic Development
risk factors
metabolism
corn
Population
Fusarium
folate-binding proteins
Guatemala
tortillas

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo : A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize. / Marasas, Walter F O; Riley, Ronald T.; Hendricks, Katherine A.; Stevens, Victoria L.; Sadler, Thomas W.; Gelineau-van Waes, Janee; Missmer, Stacey A.; Cabrera, Julio; Torres, Olga; Gelderblom, Wentzel C A; Allegood, Jeremy; Martínez, Carolina; Maddox, Joyce; Miller, J. David; Starr, Lois; Sullards, M. Cameron; Roman, Ana Victoria; Voss, Kenneth A.; Wang, Elaine; Merrill, Alfred H.

In: Journal of Nutrition, Vol. 134, No. 4, 04.2004, p. 711-716.

Research output: Contribution to journalReview article

Marasas, WFO, Riley, RT, Hendricks, KA, Stevens, VL, Sadler, TW, Gelineau-van Waes, J, Missmer, SA, Cabrera, J, Torres, O, Gelderblom, WCA, Allegood, J, Martínez, C, Maddox, J, Miller, JD, Starr, L, Sullards, MC, Roman, AV, Voss, KA, Wang, E & Merrill, AH 2004, 'Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo: A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize', Journal of Nutrition, vol. 134, no. 4, pp. 711-716.
Marasas, Walter F O ; Riley, Ronald T. ; Hendricks, Katherine A. ; Stevens, Victoria L. ; Sadler, Thomas W. ; Gelineau-van Waes, Janee ; Missmer, Stacey A. ; Cabrera, Julio ; Torres, Olga ; Gelderblom, Wentzel C A ; Allegood, Jeremy ; Martínez, Carolina ; Maddox, Joyce ; Miller, J. David ; Starr, Lois ; Sullards, M. Cameron ; Roman, Ana Victoria ; Voss, Kenneth A. ; Wang, Elaine ; Merrill, Alfred H. / Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo : A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize. In: Journal of Nutrition. 2004 ; Vol. 134, No. 4. pp. 711-716.
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abstract = "Fumonisins are a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly Fusarium moniliforme), a common fungal contaminant of maize. Fumonisins inhibit ceramide synthase, causing accumulation of bioactive intermediates of sphingolipid metabolism (sphinganine and other sphingoid bases and derivatives) as well as depletion of complex sphingolipids, which interferes with the function of some membrane proteins, including the folate-binding protein (human folate receptor α). Fumonisin causes neural tube and craniofacial defects in mouse embryos in culture. Many of these effects are prevented by supplemental folic acid. Recent studies in LMBc mice found that fumonisin exposure in utero increases the frequency of developmental defects and administration of folate or a complex sphingolipid is preventive. High incidences of neural tube defects (NTD) occur in some regions of the world where substantial consumption of fumonisins has been documented or plausibly suggested (Guatemala, South Africa, and China); furthermore, a recent study of NTD in border counties of Texas found a significant association between NTD and consumption of tortillas during the first trimester. Hence, we propose that fumonisins are potential risk factors for NTD, craniofacial anomalies, and other birth defects arising from neural crest cells because of their apparent interference with folate utilization.",
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T2 - A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize

AU - Marasas, Walter F O

AU - Riley, Ronald T.

AU - Hendricks, Katherine A.

AU - Stevens, Victoria L.

AU - Sadler, Thomas W.

AU - Gelineau-van Waes, Janee

AU - Missmer, Stacey A.

AU - Cabrera, Julio

AU - Torres, Olga

AU - Gelderblom, Wentzel C A

AU - Allegood, Jeremy

AU - Martínez, Carolina

AU - Maddox, Joyce

AU - Miller, J. David

AU - Starr, Lois

AU - Sullards, M. Cameron

AU - Roman, Ana Victoria

AU - Voss, Kenneth A.

AU - Wang, Elaine

AU - Merrill, Alfred H.

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N2 - Fumonisins are a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly Fusarium moniliforme), a common fungal contaminant of maize. Fumonisins inhibit ceramide synthase, causing accumulation of bioactive intermediates of sphingolipid metabolism (sphinganine and other sphingoid bases and derivatives) as well as depletion of complex sphingolipids, which interferes with the function of some membrane proteins, including the folate-binding protein (human folate receptor α). Fumonisin causes neural tube and craniofacial defects in mouse embryos in culture. Many of these effects are prevented by supplemental folic acid. Recent studies in LMBc mice found that fumonisin exposure in utero increases the frequency of developmental defects and administration of folate or a complex sphingolipid is preventive. High incidences of neural tube defects (NTD) occur in some regions of the world where substantial consumption of fumonisins has been documented or plausibly suggested (Guatemala, South Africa, and China); furthermore, a recent study of NTD in border counties of Texas found a significant association between NTD and consumption of tortillas during the first trimester. Hence, we propose that fumonisins are potential risk factors for NTD, craniofacial anomalies, and other birth defects arising from neural crest cells because of their apparent interference with folate utilization.

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