Functional indices of vitamin D status and ramifications of vitamin D deficiency.

Robert P. Heaney

Research output: Contribution to journalReview article

308 Citations (Scopus)

Abstract

Serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations are currently recognized as the functional status indicator for vitamin D. Evidence is reviewed that shows that serum 25(OH)D3 concentrations of <80 nmol/L are associated with reduced calcium absorption, osteoporosis, and increased fracture risk. For typical older individuals, supplemental oral intakes of approximately 1300 IU/d are required to reach the lower end of the optimal range. Evidence of substantial problems in routine clinical measurement of serum 25(OH)D3 concentrations among patients is cited. There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D3 concentrations.

Original languageEnglish
JournalAmerican Journal of Clinical Nutrition
Volume80
Issue number6 Suppl
StatePublished - Dec 2004

Fingerprint

vitamin D deficiency
Vitamin D Deficiency
vitamin D
Vitamin D
functional status
25-hydroxycholecalciferol
osteoporosis
Serum
standardization
reproducibility
mouth
Calcifediol
calcium
Osteoporosis
Calcium

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)

Cite this

Functional indices of vitamin D status and ramifications of vitamin D deficiency. / Heaney, Robert P.

In: American Journal of Clinical Nutrition, Vol. 80, No. 6 Suppl, 12.2004.

Research output: Contribution to journalReview article

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