Gardner-Diamond syndrome

a systematic review of treatment options for a rare psychodermatological disorder

Megan E. Block, Jenna L. Sitenga, Michael Lehrer, Peter T. Silberstein

Research output: Contribution to journalArticle

Abstract

Gardner-Diamond syndrome (GDS) is a rare psychodermatological condition characterized by the formation of spontaneous, painful skin lesions that develop into ecchymosis following episodes of severe physiological or psychological stress. The majority of GDS cases occur in young adult females, and although the etiology of this rare disorder is unknown, there appears to be a psychological component correlated with the coexistence of previous psychiatric diagnoses. Due to the rare nature of this disorder, there exist few guidelines for prompt clinical diagnosis and optimal treatment. Here, a systematic review was conducted to include 45 cases of patients with GDS to better understand clinical presentation as well as current treatment options. Ultimately, GDS is a diagnosis of exclusion after other coagulopathies and causes of purpura are ruled out. High clinical suspicion following laboratory and clinical exclusion of known physiological causes is necessary for diagnosis. Selective serotonin reuptake inhibitors (SSRIs) and corticosteroids are cost effective first line treatments for GDS with proven efficacy in symptomatic relief. GDS refractory to initial treatment may require regular psychotherapy and titrated SSRI dosages to achieve long-term success. This review of available case studies serves to comprehensively describe the clinical presentation and available treatment approaches to this rare psychodermatological disorder.

Original languageEnglish (US)
JournalInternational Journal of Dermatology
DOIs
StateAccepted/In press - Jan 1 2018

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Serotonin Uptake Inhibitors
Therapeutics
Ecchymosis
Physiological Stress
Purpura
Psychological Stress
Mental Disorders
Psychotherapy
Gardner-Diamond syndrome
Young Adult
Adrenal Cortex Hormones
Guidelines
Psychology
Costs and Cost Analysis
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Gardner-Diamond syndrome : a systematic review of treatment options for a rare psychodermatological disorder. / Block, Megan E.; Sitenga, Jenna L.; Lehrer, Michael; Silberstein, Peter T.

In: International Journal of Dermatology, 01.01.2018.

Research output: Contribution to journalArticle

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