Gender specific LRP5 influences on trabecular bone structure and strength

S. A. Dubrow, P. M. Hruby, M. P. Akhter

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properties of trabecular and cortical bone in femurs and vertebrae (L5) of 17-week-old mice. Micro-computed tomography was used to evaluate the trabecular bone structure of distal femurs and vertebrae ex vivo. Mechanical testing of the trabecular bone in the distal femur was done to determine biomechanical strength. Differences due to genotype and gender were tested using two-way ANOVA at a significance level of p

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalJournal of Musculoskeletal Neuronal Interactions
Volume7
Issue number2
StatePublished - Apr 1 2007

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine

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