Abstract
A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properties of trabecular and cortical bone in femurs and vertebrae (L5) of 17-week-old mice. Micro-computed tomography was used to evaluate the trabecular bone structure of distal femurs and vertebrae ex vivo. Mechanical testing of the trabecular bone in the distal femur was done to determine biomechanical strength. Differences due to genotype and gender were tested using two-way ANOVA at a significance level of p
| Original language | English |
|---|---|
| Pages (from-to) | 166-173 |
| Number of pages | 8 |
| Journal | Journal of Musculoskeletal Neuronal Interactions |
| Volume | 7 |
| Issue number | 2 |
| State | Published - Apr 2007 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Endocrinology
Cite this
Gender specific LRP5 influences on trabecular bone structure and strength. / Dubrow, S. A.; Hruby, P. M.; Akhter, Mohammed P.
In: Journal of Musculoskeletal Neuronal Interactions, Vol. 7, No. 2, 04.2007, p. 166-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gender specific LRP5 influences on trabecular bone structure and strength
AU - Dubrow, S. A.
AU - Hruby, P. M.
AU - Akhter, Mohammed P.
PY - 2007/4
Y1 - 2007/4
N2 - A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properties of trabecular and cortical bone in femurs and vertebrae (L5) of 17-week-old mice. Micro-computed tomography was used to evaluate the trabecular bone structure of distal femurs and vertebrae ex vivo. Mechanical testing of the trabecular bone in the distal femur was done to determine biomechanical strength. Differences due to genotype and gender were tested using two-way ANOVA at a significance level of p
AB - A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properties of trabecular and cortical bone in femurs and vertebrae (L5) of 17-week-old mice. Micro-computed tomography was used to evaluate the trabecular bone structure of distal femurs and vertebrae ex vivo. Mechanical testing of the trabecular bone in the distal femur was done to determine biomechanical strength. Differences due to genotype and gender were tested using two-way ANOVA at a significance level of p
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M3 - Article
VL - 7
SP - 166
EP - 173
JO - Journal of Musculoskeletal Neuronal Interactions
JF - Journal of Musculoskeletal Neuronal Interactions
SN - 1108-7161
IS - 2
ER -