Gender specific LRP5 influences on trabecular bone structure and strength

S. A. Dubrow, P. M. Hruby, Mohammed P. Akhter

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properties of trabecular and cortical bone in femurs and vertebrae (L5) of 17-week-old mice. Micro-computed tomography was used to evaluate the trabecular bone structure of distal femurs and vertebrae ex vivo. Mechanical testing of the trabecular bone in the distal femur was done to determine biomechanical strength. Differences due to genotype and gender were tested using two-way ANOVA at a significance level of p

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalJournal of Musculoskeletal Neuronal Interactions
Volume7
Issue number2
StatePublished - Apr 2007

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Low Density Lipoprotein Receptor-Related Protein-5
Femur
Spine
Mutation
Bone Density
Transgenic Mice
Analysis of Variance
Genotype
Tomography
Bone and Bones
Genes
Cancellous Bone

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Endocrinology

Cite this

Gender specific LRP5 influences on trabecular bone structure and strength. / Dubrow, S. A.; Hruby, P. M.; Akhter, Mohammed P.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 7, No. 2, 04.2007, p. 166-173.

Research output: Contribution to journalArticle

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