Gene manipulation and genetic toxicology

Raymond W. Tennant, Laura Hansen, Judson Spalding

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Transgenic mice with recoverable target genes, with genes modified in expression or with ablated gene function provide important tools for defining the biological effects of chemicals. In many cases studies can be conducted with fewer animals and in a shorter timeframe. They also provide important tools for studies of carcinogenesis mechanisms and processes, for early detection of carcinogens and for identification of potential cancer therapies.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
Issue number3
StatePublished - May 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Toxicology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis


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