Abstract
Osteoporosis is a disease characterized by fragile bones and high susceptibility to low trauma fractures. It is a serious health problem, especially in elderly women. Bone mineral density (BMD) has been employed most commonly as the index for defining and studying osteoporosis. In this presentation, we use examples of our studies in both Caucasians and Chinese to illustrate the approaches used and some main results obtained on 1) characterizing the degree and the inheritance mode of genetic determination of a complex trait such as BMD; 2) identifying and mapping genes for osteoporosis. The purpose of the presentation is to introduce to the medical researchers how and what modern genetics can do to disentangle the mist of an array of genetics factors, the major determinants, for BMD.
| Original language | English |
|---|---|
| Pages (from-to) | 91-100 |
| Number of pages | 10 |
| Journal | Journal of Musculoskeletal Neuronal Interactions |
| Volume | 4 |
| Issue number | 1 |
| State | Published - Mar 2004 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Endocrinology
Cite this
Gene mapping and identification for osteoporosis. / Deng, Hong Wen; Recker, Robert R.
In: Journal of Musculoskeletal Neuronal Interactions, Vol. 4, No. 1, 03.2004, p. 91-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene mapping and identification for osteoporosis
AU - Deng, Hong Wen
AU - Recker, Robert R.
PY - 2004/3
Y1 - 2004/3
N2 - Osteoporosis is a disease characterized by fragile bones and high susceptibility to low trauma fractures. It is a serious health problem, especially in elderly women. Bone mineral density (BMD) has been employed most commonly as the index for defining and studying osteoporosis. In this presentation, we use examples of our studies in both Caucasians and Chinese to illustrate the approaches used and some main results obtained on 1) characterizing the degree and the inheritance mode of genetic determination of a complex trait such as BMD; 2) identifying and mapping genes for osteoporosis. The purpose of the presentation is to introduce to the medical researchers how and what modern genetics can do to disentangle the mist of an array of genetics factors, the major determinants, for BMD.
AB - Osteoporosis is a disease characterized by fragile bones and high susceptibility to low trauma fractures. It is a serious health problem, especially in elderly women. Bone mineral density (BMD) has been employed most commonly as the index for defining and studying osteoporosis. In this presentation, we use examples of our studies in both Caucasians and Chinese to illustrate the approaches used and some main results obtained on 1) characterizing the degree and the inheritance mode of genetic determination of a complex trait such as BMD; 2) identifying and mapping genes for osteoporosis. The purpose of the presentation is to introduce to the medical researchers how and what modern genetics can do to disentangle the mist of an array of genetics factors, the major determinants, for BMD.
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UR - http://www.scopus.com/inward/citedby.url?scp=2642551687&partnerID=8YFLogxK
M3 - Article
C2 - 15615082
AN - SCOPUS:2642551687
VL - 4
SP - 91
EP - 100
JO - Journal of Musculoskeletal Neuronal Interactions
JF - Journal of Musculoskeletal Neuronal Interactions
SN - 1108-7161
IS - 1
ER -