Genetic and environmental correlations between obesity phenotypes and age at menarche

W. Wang, L. J. Zhao, Y. Z. Liu, Robert R. Recker, H. W. Deng

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To assess the extent that the genetic and environmental factors contribute to the phenotypic correlations between obesity traits and age at menarche (AAM), and also to examine the influence of AAM on obesity in both pre- and postmenopausal women. Methods: Five hundred and twelve pedigrees with 2667 Caucasian female subjects from two to four generations were recruited. Fat mass and lean mass (both in kg) were measured by dual-energy X-ray absorptiometry scanner. Body mass index (BMI) (kg/m2) was calculated. We performed bivariate quantitative genetic analyses in the total sample containing 2667 Caucasian women. We also selected 206 unrelated premenopausal women and 140 unrelated postmenopausal women from the total sample, and computed the respective phenotypic correlation between obesity and AAM in these two subgroups. Results: For fat mass, lean mass and BMI, we detected their significant negative genetic correlations with AAM after adjustment for significant covariates, which were -0.3170 (P0.05), ranging from -0.0016 to 0.0192. In the premenopausal subgroup, significant associations were observed between fat mass and AAM (ρ=-0.231, P

Original languageEnglish
Pages (from-to)1595-1600
Number of pages6
JournalInternational Journal of Obesity
Volume30
Issue number11
DOIs
StatePublished - Oct 25 2006

Fingerprint

menarche
Menarche
obesity
Obesity
Phenotype
phenotype
Fats
phenotypic correlation
body mass index
Body Mass Index
lipids
dual-energy X-ray absorptiometry
Photon Absorptiometry
scanners
quantitative genetics
Pedigree
pedigree
genetic correlation
sampling
environmental factors

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Genetic and environmental correlations between obesity phenotypes and age at menarche. / Wang, W.; Zhao, L. J.; Liu, Y. Z.; Recker, Robert R.; Deng, H. W.

In: International Journal of Obesity, Vol. 30, No. 11, 25.10.2006, p. 1595-1600.

Research output: Contribution to journalArticle

Wang, W. ; Zhao, L. J. ; Liu, Y. Z. ; Recker, Robert R. ; Deng, H. W. / Genetic and environmental correlations between obesity phenotypes and age at menarche. In: International Journal of Obesity. 2006 ; Vol. 30, No. 11. pp. 1595-1600.
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