Genetic and immunopathological findings in a lymphoma family

H. T. Lynch; J. N. Marcus; D. D. Weisenburger; P. Watson; M. L. Fitzsimmons; H. Grierson; D. M. Smith; J. Lynch; D. Purtilo

doi:10.1038/bjc.1989.126

Genetic and immunopathological findings in a lymphoma family

H. T. Lynch, J. N. Marcus, D. D. Weisenburger, P. Watson, M. L. Fitzsimmons, H. Grierson, D. M. Smith, J. Lynch, D. Purtilo

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG₃level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

Original language	English (US)
Pages (from-to)	622-626
Number of pages	5
Journal	British Journal of Cancer
Volume	59
Issue number	4
DOIs	https://doi.org/10.1038/bjc.1989.126
State	Published - Apr 1989

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1038/bjc.1989.126

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title = "Genetic and immunopathological findings in a lymphoma family",

abstract = "We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin{\textquoteright}s lymphoma, while a granddaughter had Hodgkin{\textquoteright}s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.",

author = "Lynch, {H. T.} and Marcus, {J. N.} and Weisenburger, {D. D.} and P. Watson and Fitzsimmons, {M. L.} and H. Grierson and Smith, {D. M.} and J. Lynch and D. Purtilo",

note = "Funding Information: This study was supported in part by grants from the Health Futures Foundation.",

year = "1989",

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doi = "10.1038/bjc.1989.126",

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T1 - Genetic and immunopathological findings in a lymphoma family

AU - Lynch, H. T.

AU - Marcus, J. N.

AU - Weisenburger, D. D.

AU - Watson, P.

AU - Fitzsimmons, M. L.

AU - Grierson, H.

AU - Smith, D. M.

AU - Lynch, J.

AU - Purtilo, D.

N1 - Funding Information: This study was supported in part by grants from the Health Futures Foundation.

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N2 - We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

AB - We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

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