Genetic and immunopathological findings in a lymphoma family

H. T. Lynch, J. N. Marcus, D. D. Weisenburger, P. Watson, M. L. Fitzsimmons, H. Grierson, D. M. Smith, J. Lynch, D. Purtilo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

Original languageEnglish (US)
Pages (from-to)622-626
Number of pages5
JournalBritish Journal of Cancer
Issue number4
StatePublished - Apr 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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