Abstract
We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
Original language | English (US) |
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Pages (from-to) | 622-626 |
Number of pages | 5 |
Journal | British Journal of Cancer |
Volume | 59 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1989 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research