Genetic and immunopathological findings in a lymphoma family

H. T. Lynch; J. N. Marcus; D. D. Weisenburger; P. Watson; M. L. Fitzsimmons; H. Grierson; D. M. Smith; J. Lynch; D. Purtilo

doi:10.1038/bjc.1989.126

Genetic and immunopathological findings in a lymphoma family

H. T. Lynch, J. N. Marcus, D. D. Weisenburger, P. Watson, M. L. Fitzsimmons, H. Grierson, D. M. Smith, J. Lynch, D. Purtilo

Department of Preventive Medicine

Research output: Contribution to journal › Article

11 Scopus citations

Abstract

We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG₃level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

Original language	English (US)
Pages (from-to)	622-626
Number of pages	5
Journal	British Journal of Cancer
Volume	59
Issue number	4
DOIs	https://doi.org/10.1038/bjc.1989.126
State	Published - Apr 1989

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1038/bjc.1989.126

Fingerprint Dive into the research topics of 'Genetic and immunopathological findings in a lymphoma family'. Together they form a unique fingerprint.

Cite this

Lynch, H. T., Marcus, J. N., Weisenburger, D. D., Watson, P., Fitzsimmons, M. L., Grierson, H., Smith, D. M., Lynch, J., & Purtilo, D. (1989). Genetic and immunopathological findings in a lymphoma family. British Journal of Cancer, 59(4), 622-626. https://doi.org/10.1038/bjc.1989.126

@article{1c7e1690ee804678ad89f478ab009b77,

title = "Genetic and immunopathological findings in a lymphoma family",

abstract = "We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin{\textquoteright}s lymphoma, while a granddaughter had Hodgkin{\textquoteright}s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.",

author = "Lynch, {H. T.} and Marcus, {J. N.} and Weisenburger, {D. D.} and P. Watson and Fitzsimmons, {M. L.} and H. Grierson and Smith, {D. M.} and J. Lynch and D. Purtilo",

year = "1989",

month = apr,

doi = "10.1038/bjc.1989.126",

language = "English (US)",

volume = "59",

pages = "622--626",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Genetic and immunopathological findings in a lymphoma family

AU - Lynch, H. T.

AU - Marcus, J. N.

AU - Weisenburger, D. D.

AU - Watson, P.

AU - Fitzsimmons, M. L.

AU - Grierson, H.

AU - Smith, D. M.

AU - Lynch, J.

AU - Purtilo, D.

PY - 1989/4

Y1 - 1989/4

N2 - We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

AB - We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

UR - http://www.scopus.com/inward/record.url?scp=0024542942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024542942&partnerID=8YFLogxK

U2 - 10.1038/bjc.1989.126

DO - 10.1038/bjc.1989.126

M3 - Article

C2 - 2713249

AN - SCOPUS:0024542942

VL - 59

SP - 622

EP - 626

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 4

ER -