Genetic and immunopathological findings in a lymphoma family

H. T. Lynch, J. N. Marcus, D. D. Weisenburger, P. Watson, M. L. Fitzsimmons, H. Grierson, D. M. Smith, J. Lynch, D. Purtilo

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Abstract

We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

Original languageEnglish (US)
Pages (from-to)622-626
Number of pages5
JournalBritish Journal of Cancer
Volume59
Issue number4
DOIs
StatePublished - Apr 1989

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Lynch, H. T., Marcus, J. N., Weisenburger, D. D., Watson, P., Fitzsimmons, M. L., Grierson, H., Smith, D. M., Lynch, J., & Purtilo, D. (1989). Genetic and immunopathological findings in a lymphoma family. British Journal of Cancer, 59(4), 622-626. https://doi.org/10.1038/bjc.1989.126