Abstract
We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
| Original language | English |
|---|---|
| Pages (from-to) | 622-626 |
| Number of pages | 5 |
| Journal | British Journal of Cancer |
| Volume | 59 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1989 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
Genetic and immunopathological findings in a lymphoma family. / Lynch, Henry T.; Marcus, J. N.; Weisenburger, D. D.; Watson, P.; Fitzsimmons, M. L.; Grierson, H.; Smith, D. M.; Lynch, J.; Purtilo, D.
In: British Journal of Cancer, Vol. 59, No. 4, 1989, p. 622-626.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic and immunopathological findings in a lymphoma family
AU - Lynch, Henry T.
AU - Marcus, J. N.
AU - Weisenburger, D. D.
AU - Watson, P.
AU - Fitzsimmons, M. L.
AU - Grierson, H.
AU - Smith, D. M.
AU - Lynch, J.
AU - Purtilo, D.
PY - 1989
Y1 - 1989
N2 - We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
AB - We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
UR - http://www.scopus.com/inward/record.url?scp=0024542942&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024542942&partnerID=8YFLogxK
U2 - 10.1038/bjc.1989.126
DO - 10.1038/bjc.1989.126
M3 - Article
C2 - 2713249
AN - SCOPUS:0024542942
VL - 59
SP - 622
EP - 626
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 4
ER -