Genetic and immunopathological findings in a lymphoma family

Henry T. Lynch, J. N. Marcus, D. D. Weisenburger, P. Watson, M. L. Fitzsimmons, H. Grierson, D. M. Smith, J. Lynch, D. Purtilo

Research output: Contribution to journalArticle

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Abstract

We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin’s lymphoma, while a granddaughter had Hodgkin’s disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

Original languageEnglish
Pages (from-to)622-626
Number of pages5
JournalBritish Journal of Cancer
Volume59
Issue number4
DOIs
StatePublished - 1989

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Lymphoma
Pokeweed Mitogens
Lymphocyte Activation
Concanavalin A
Hodgkin Disease
Spouses
Non-Hodgkin's Lymphoma
Survivors
Siblings
Mothers
Serum

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Marcus, J. N., Weisenburger, D. D., Watson, P., Fitzsimmons, M. L., Grierson, H., ... Purtilo, D. (1989). Genetic and immunopathological findings in a lymphoma family. British Journal of Cancer, 59(4), 622-626. https://doi.org/10.1038/bjc.1989.126

Genetic and immunopathological findings in a lymphoma family. / Lynch, Henry T.; Marcus, J. N.; Weisenburger, D. D.; Watson, P.; Fitzsimmons, M. L.; Grierson, H.; Smith, D. M.; Lynch, J.; Purtilo, D.

In: British Journal of Cancer, Vol. 59, No. 4, 1989, p. 622-626.

Research output: Contribution to journalArticle

Lynch, HT, Marcus, JN, Weisenburger, DD, Watson, P, Fitzsimmons, ML, Grierson, H, Smith, DM, Lynch, J & Purtilo, D 1989, 'Genetic and immunopathological findings in a lymphoma family', British Journal of Cancer, vol. 59, no. 4, pp. 622-626. https://doi.org/10.1038/bjc.1989.126
Lynch HT, Marcus JN, Weisenburger DD, Watson P, Fitzsimmons ML, Grierson H et al. Genetic and immunopathological findings in a lymphoma family. British Journal of Cancer. 1989;59(4):622-626. https://doi.org/10.1038/bjc.1989.126
Lynch, Henry T. ; Marcus, J. N. ; Weisenburger, D. D. ; Watson, P. ; Fitzsimmons, M. L. ; Grierson, H. ; Smith, D. M. ; Lynch, J. ; Purtilo, D. / Genetic and immunopathological findings in a lymphoma family. In: British Journal of Cancer. 1989 ; Vol. 59, No. 4. pp. 622-626.
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