Genetic control of chromosomal and plasmid recombination in Staphylococcus aureus

L. Wyman, Richard V. Goering, R. P. Novick

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Recombination deficient mutants of Staphylococcus aureus were isolated and found to have properties similar to those of recombination deficient Escherichia coli. In addition, one Rec- mutant was found to be defective in the restriction and modification of DNA. There is a marked reduction (104 fold) in recombination between penicillinase plasmids in the Rec- mutants suggesting that these elements do not encode an efficient recombination system. There is, however, a demonstrable residuum of interplasmid recombination; evidence is lacking on whether this residuum is a plasmid or host function. In the absence of the generalized host recombination system it was possible to demonstrate that interplasmid recombination occurs during vegetative bacteriophage growth and is presumably mediated by a phage determined recombination system.

Original languageEnglish
Pages (from-to)681-702
Number of pages22
JournalGenetics
Volume76
Issue number4
StatePublished - 1974
Externally publishedYes

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Genetic Recombination
Staphylococcus aureus
Plasmids
Bacteriophages
Penicillinase
Escherichia coli
DNA
Growth

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Genetic control of chromosomal and plasmid recombination in Staphylococcus aureus. / Wyman, L.; Goering, Richard V.; Novick, R. P.

In: Genetics, Vol. 76, No. 4, 1974, p. 681-702.

Research output: Contribution to journalArticle

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