Genetic counseling for hereditary cancer

Henry T. Lynch, Jane Lynch

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This paper provides an overview of the current approach to genetic counseling for cancer, using hereditary nonpolyposis colorectal cancer (HNPCC) as a prototype. Heretofore, when evaluating the possibility of an HNPCC diagnosis, physicians had to rely exclusively on a detailed family history of cancer in the context of an extended pedigree. Patients in the direct genetic lineage who had one or more first-degree relatives with an HNPCC syndrome cancer were told that they had a 50% likelihood of inheriting the deleterious gene. However, with the discovery of the HNPCC genes (hMSH2, hMLH1, hPMS1, hPMS2), genetic counseling can now provide a more precise determination of a patient's lifetime cancer destiny. Since these DNA findings are new, guidelines for sharing this information with patients remain preliminary. One must be certain that the patient wants to receive DNA information and that he or she is aware of potential discrimination by insurance companies and employers, as well as the possibility of psychological sequelae.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalOncology
Volume10
Issue number1
StatePublished - Jan 1996

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Genetic Counseling
Neoplasms
Information Dissemination
Neoplasm Genes
DNA
Pedigree
Insurance
Guidelines
Psychology
Physicians
Genes

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Lynch, H. T., & Lynch, J. (1996). Genetic counseling for hereditary cancer. Oncology, 10(1), 27-34.

Genetic counseling for hereditary cancer. / Lynch, Henry T.; Lynch, Jane.

In: Oncology, Vol. 10, No. 1, 01.1996, p. 27-34.

Research output: Contribution to journalArticle

Lynch, HT & Lynch, J 1996, 'Genetic counseling for hereditary cancer', Oncology, vol. 10, no. 1, pp. 27-34.
Lynch, Henry T. ; Lynch, Jane. / Genetic counseling for hereditary cancer. In: Oncology. 1996 ; Vol. 10, No. 1. pp. 27-34.
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