Genetic diagnosis of Lynch syndrome II in an extended colorectal cancer-prone family

Henry T. Lynch, E. K. Bronson, P. C. Strayhorn, T. C. Smyrk, J. F. Lynch, E. J. Ploetner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Knowledge of colon cancer genetics, with particular attention to precision in hereditary cancer syndrome diagnosis, can often enable highly targeted surveillance and management strategies for patients at high genetic risk. Unfortunately, the patient's family history of cancer is often given minimal attention, and knowledge of hereditary cancer syndromes is frequently limited. Indeed, many physicians still consider familial adenomatous polyposis (FAP) as the only genetic risk factor for colorectal cancer. This concern with FAP was noted in a colorectal cancer-prone kindred which for decades has been thought to manifest that syndrome. However, after meticulous genetic, medical, and pathologic studies, the cardinal phenotypic characteristics of Lynch syndrome II were observed. The potential for cancer control in current and future generations of families like this one clearly mandates the need for computerized registries which could transmit current information about hereditary colon cancer syndrome diagnosis, surveillance, and management.

Original languageEnglish
Pages (from-to)2233-2238
Number of pages6
JournalCancer
Volume66
Issue number10
DOIs
StatePublished - 1990

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Lynch Syndrome II
Hereditary Neoplastic Syndromes
Colorectal Neoplasms
Adenomatous Polyposis Coli
Colonic Neoplasms
Social Responsibility
Medical Genetics
Registries
Neoplasms
Physicians

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Genetic diagnosis of Lynch syndrome II in an extended colorectal cancer-prone family. / Lynch, Henry T.; Bronson, E. K.; Strayhorn, P. C.; Smyrk, T. C.; Lynch, J. F.; Ploetner, E. J.

In: Cancer, Vol. 66, No. 10, 1990, p. 2233-2238.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Bronson, E. K. ; Strayhorn, P. C. ; Smyrk, T. C. ; Lynch, J. F. ; Ploetner, E. J. / Genetic diagnosis of Lynch syndrome II in an extended colorectal cancer-prone family. In: Cancer. 1990 ; Vol. 66, No. 10. pp. 2233-2238.
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