Genetic dissection of human stature in a large sample of multiplex pedigrees

Yao Zhong Liu, Fu Hua Xu, Hui Shen, Yong Jun Liu, Lan Juan Zhao, Ji Rong Long, Yuan Yuan Zhang, Peng Xiao, Dong Hai Xiong, Volodymyr Dvornyk, Jin Long Li, Theresa Conway, K. Michael Davies, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Recently, we reported a whole genome scan on a sample of 630 Caucasian subjects from 53 human pedigrees. Several genomic regions were suggested to be linked to height. In an attempt to confirm the identified genomic regions, as well as to identify new genomic regions linked to height, we conducted a whole genome linkage study on an extended sample of 1,816 subjects from 79 pedigrees, which includes the 53 pedigrees containing the original 630 subjects from our previous whole genome study and an additional 128 new subjects, and 26 further pedigrees containing 1,058 subjects. Several regions achieved suggestive linkage signals, such as 9q22.32 [MLS (multipoint LOD score) = 2.74], 9q34.3 [MLS = 2.66], Xq24 [two-point LOD score = 2.64 at the marker DXS8067], and 7p14.2 [MLS = 2.051. The importance of the above regions is supported either by other whole genome studies or by candidate genes within these regions relevant to linear growth or pathogenesis of short stature. In addition, this study has tentatively confirmed the Xq24 region's linkage to height, as this region was also detected in the previous whole genome study. To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature.

Original languageEnglish
Pages (from-to)472-488
Number of pages17
JournalAnnals of Human Genetics
Volume68
Issue number5
DOIs
StatePublished - Sep 2004

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Medical Genetics
Pedigree
Dissection
Genome
Genetic Linkage
Sample Size
Growth
Genes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics

Cite this

Liu, Y. Z., Xu, F. H., Shen, H., Liu, Y. J., Zhao, L. J., Long, J. R., ... Deng, H. W. (2004). Genetic dissection of human stature in a large sample of multiplex pedigrees. Annals of Human Genetics, 68(5), 472-488. https://doi.org/10.1046/j.1529-8817.2003.00117.x

Genetic dissection of human stature in a large sample of multiplex pedigrees. / Liu, Yao Zhong; Xu, Fu Hua; Shen, Hui; Liu, Yong Jun; Zhao, Lan Juan; Long, Ji Rong; Zhang, Yuan Yuan; Xiao, Peng; Xiong, Dong Hai; Dvornyk, Volodymyr; Li, Jin Long; Conway, Theresa; Davies, K. Michael; Recker, Robert R.; Deng, Hong Wen.

In: Annals of Human Genetics, Vol. 68, No. 5, 09.2004, p. 472-488.

Research output: Contribution to journalArticle

Liu, YZ, Xu, FH, Shen, H, Liu, YJ, Zhao, LJ, Long, JR, Zhang, YY, Xiao, P, Xiong, DH, Dvornyk, V, Li, JL, Conway, T, Davies, KM, Recker, RR & Deng, HW 2004, 'Genetic dissection of human stature in a large sample of multiplex pedigrees', Annals of Human Genetics, vol. 68, no. 5, pp. 472-488. https://doi.org/10.1046/j.1529-8817.2003.00117.x
Liu, Yao Zhong ; Xu, Fu Hua ; Shen, Hui ; Liu, Yong Jun ; Zhao, Lan Juan ; Long, Ji Rong ; Zhang, Yuan Yuan ; Xiao, Peng ; Xiong, Dong Hai ; Dvornyk, Volodymyr ; Li, Jin Long ; Conway, Theresa ; Davies, K. Michael ; Recker, Robert R. ; Deng, Hong Wen. / Genetic dissection of human stature in a large sample of multiplex pedigrees. In: Annals of Human Genetics. 2004 ; Vol. 68, No. 5. pp. 472-488.
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