Genetic epidemiology of breast cancer and associated cancers in high-risk families. II. Linkage analysis

M. C. King, R. C P Go, Henry T. Lynch, R. C. Elston, P. I. Terasaki, N. L. Petrakis, G. C. Rodgers, D. Lattanzio, J. Bailey-Wilson

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Abstract

Chromosomal locations of hypothetical alleles which increase suspectibility to human breast cancer in some families were investigated by genetic linkage analysis. In 7 families with primarily premenopausal breast cancer and (in 5 families) ovarian cancer, a dominant susceptibility allele may be linked to the genetic marker glutamic-pyruvic transaminase or alanine aminotransferase (GPT; lod score 1.95 at zero recombination). The most positive lod score for linkage to a recessive susceptibility allele was for acid phosphatase (ACP; lod score 0.78 at 40% recombination), but ACP was informative in only 1 family. In 3 families with primarily postmenopausal breast cancer, none of 21 genetic markers provided any evidence for linkage to either dominant or recessive susceptibility alleles. In the families with the possible GPT linkage, women who carry the hypothetical susceptibility allele would be at high risk of breast cancer, whereas their relatives who do not carry that allele would have no increased risk. GPT genotype is not associated with breast cancer risk in the general population, so GPT linkage cannot be used as a screening test for breast cancer.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalJournal of the National Cancer Institute
Volume71
Issue number3
StatePublished - 1983
Externally publishedYes

Fingerprint

Molecular Epidemiology
Breast Neoplasms
Alleles
Lod Score
Neoplasms
Alanine Transaminase
Genetic Markers
Genetic Recombination
Genetic Linkage
Acid Phosphatase
Ovarian Neoplasms
Genotype
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

King, M. C., Go, R. C. P., Lynch, H. T., Elston, R. C., Terasaki, P. I., Petrakis, N. L., ... Bailey-Wilson, J. (1983). Genetic epidemiology of breast cancer and associated cancers in high-risk families. II. Linkage analysis. Journal of the National Cancer Institute, 71(3), 463-467.

Genetic epidemiology of breast cancer and associated cancers in high-risk families. II. Linkage analysis. / King, M. C.; Go, R. C P; Lynch, Henry T.; Elston, R. C.; Terasaki, P. I.; Petrakis, N. L.; Rodgers, G. C.; Lattanzio, D.; Bailey-Wilson, J.

In: Journal of the National Cancer Institute, Vol. 71, No. 3, 1983, p. 463-467.

Research output: Contribution to journalArticle

King, MC, Go, RCP, Lynch, HT, Elston, RC, Terasaki, PI, Petrakis, NL, Rodgers, GC, Lattanzio, D & Bailey-Wilson, J 1983, 'Genetic epidemiology of breast cancer and associated cancers in high-risk families. II. Linkage analysis', Journal of the National Cancer Institute, vol. 71, no. 3, pp. 463-467.
King, M. C. ; Go, R. C P ; Lynch, Henry T. ; Elston, R. C. ; Terasaki, P. I. ; Petrakis, N. L. ; Rodgers, G. C. ; Lattanzio, D. ; Bailey-Wilson, J. / Genetic epidemiology of breast cancer and associated cancers in high-risk families. II. Linkage analysis. In: Journal of the National Cancer Institute. 1983 ; Vol. 71, No. 3. pp. 463-467.
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AU - Terasaki, P. I.

AU - Petrakis, N. L.

AU - Rodgers, G. C.

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AU - Bailey-Wilson, J.

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N2 - Chromosomal locations of hypothetical alleles which increase suspectibility to human breast cancer in some families were investigated by genetic linkage analysis. In 7 families with primarily premenopausal breast cancer and (in 5 families) ovarian cancer, a dominant susceptibility allele may be linked to the genetic marker glutamic-pyruvic transaminase or alanine aminotransferase (GPT; lod score 1.95 at zero recombination). The most positive lod score for linkage to a recessive susceptibility allele was for acid phosphatase (ACP; lod score 0.78 at 40% recombination), but ACP was informative in only 1 family. In 3 families with primarily postmenopausal breast cancer, none of 21 genetic markers provided any evidence for linkage to either dominant or recessive susceptibility alleles. In the families with the possible GPT linkage, women who carry the hypothetical susceptibility allele would be at high risk of breast cancer, whereas their relatives who do not carry that allele would have no increased risk. GPT genotype is not associated with breast cancer risk in the general population, so GPT linkage cannot be used as a screening test for breast cancer.

AB - Chromosomal locations of hypothetical alleles which increase suspectibility to human breast cancer in some families were investigated by genetic linkage analysis. In 7 families with primarily premenopausal breast cancer and (in 5 families) ovarian cancer, a dominant susceptibility allele may be linked to the genetic marker glutamic-pyruvic transaminase or alanine aminotransferase (GPT; lod score 1.95 at zero recombination). The most positive lod score for linkage to a recessive susceptibility allele was for acid phosphatase (ACP; lod score 0.78 at 40% recombination), but ACP was informative in only 1 family. In 3 families with primarily postmenopausal breast cancer, none of 21 genetic markers provided any evidence for linkage to either dominant or recessive susceptibility alleles. In the families with the possible GPT linkage, women who carry the hypothetical susceptibility allele would be at high risk of breast cancer, whereas their relatives who do not carry that allele would have no increased risk. GPT genotype is not associated with breast cancer risk in the general population, so GPT linkage cannot be used as a screening test for breast cancer.

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