Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains

H. S. Lillehoj; K. Beisel; N. R. Rose

Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains

H. S. Lillehoj, K. Beisel, N. R. Rose

Research output: Contribution to journal › Article › peer-review

Abstract

CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroidits (EAT). F₁ hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F₂ and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.

Original language	English (US)
Pages (from-to)	654-659
Number of pages	6
Journal	Journal of Immunology
Volume	127
Issue number	2
State	Published - Jan 1 1981
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

Fingerprint Dive into the research topics of 'Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains'. Together they form a unique fingerprint.

Cite this

@article{627287b1503844ada32c900f9f217797,

title = "Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains",

abstract = "CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroidits (EAT). F1 hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F2 and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.",

author = "Lillehoj, {H. S.} and K. Beisel and Rose, {N. R.}",

year = "1981",

month = jan,

day = "1",

language = "English (US)",

volume = "127",

pages = "654--659",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "2",

}

TY - JOUR

T1 - Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains

AU - Lillehoj, H. S.

AU - Beisel, K.

AU - Rose, N. R.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroidits (EAT). F1 hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F2 and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.

AB - CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroidits (EAT). F1 hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F2 and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.

UR - http://www.scopus.com/inward/record.url?scp=0019456525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019456525&partnerID=8YFLogxK

M3 - Article

C2 - 6454724

AN - SCOPUS:0019456525

VL - 127

SP - 654

EP - 659

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 2

ER -

Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Cite this