Abstract
CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroidits (EAT). F1 hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F2 and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 654-659 |
| Number of pages | 6 |
| Journal | Journal of Immunology |
| Volume | 127 |
| Issue number | 2 |
| State | Published - 1981 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Immunology
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Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains. / Lillehoj, H. S.; Beisel, Kirk; Rose, N. R.
In: Journal of Immunology, Vol. 127, No. 2, 1981, p. 654-659.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains
AU - Lillehoj, H. S.
AU - Beisel, Kirk
AU - Rose, N. R.
PY - 1981
Y1 - 1981
N2 - CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroidits (EAT). F1 hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F2 and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.
AB - CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroidits (EAT). F1 hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F2 and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019456525&partnerID=8YFLogxK
M3 - Article
C2 - 6454724
AN - SCOPUS:0019456525
VL - 127
SP - 654
EP - 659
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 2
ER -