Genetic Instability of Microsatellites in Endometrial Carcinoma

John I. Risinger, Andrew Berchuck, Matthew F. Kohler, Patrice Watson, Henry T. Lynch, Jeff Boyd

Research output: Contribution to journalArticle

520 Citations (Scopus)

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by a familial predisposition to colorectal carcinoma and extracolonic cancers of the gastrointestinal, urological, and female reproductive tracts, notably the endometrium. A genetic locus for HPNCC was recently determined by linkage analysis to exist on chromosome 2p; both sporadic and HNPCC-associated colorectal carcinomas exhibit a “replication error'' phenotype, characterized by instability of dinucleotide repeat sequences throughout the genome. Here, we address the hypothesis that the replication error phenotype would be evident in some fraction of sporadic endometrial carcinomas or in those associated with HNPCC. Microsatellite instability was observed in 17% of sporadic endometrial carcinomas and in 75% of those tumors associated with HNPCC. These data indicate that the HNPCC gene is also involved in heritable and somatic forms of endometrial carcinoma.

Original languageEnglish
Pages (from-to)5100-5103
Number of pages4
JournalCancer Research
Volume53
Issue number21
StatePublished - Nov 1 1993

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Hereditary Nonpolyposis Colorectal Neoplasms
Microsatellite Instability
Endometrial Neoplasms
Colorectal Neoplasms
Urologic Neoplasms
Dinucleotide Repeats
Gastrointestinal Neoplasms
Genetic Loci
Neoplasm Genes
Endometrium
Chromosomes
Genome
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Risinger, J. I., Berchuck, A., Kohler, M. F., Watson, P., Lynch, H. T., & Boyd, J. (1993). Genetic Instability of Microsatellites in Endometrial Carcinoma. Cancer Research, 53(21), 5100-5103.

Genetic Instability of Microsatellites in Endometrial Carcinoma. / Risinger, John I.; Berchuck, Andrew; Kohler, Matthew F.; Watson, Patrice; Lynch, Henry T.; Boyd, Jeff.

In: Cancer Research, Vol. 53, No. 21, 01.11.1993, p. 5100-5103.

Research output: Contribution to journalArticle

Risinger, JI, Berchuck, A, Kohler, MF, Watson, P, Lynch, HT & Boyd, J 1993, 'Genetic Instability of Microsatellites in Endometrial Carcinoma', Cancer Research, vol. 53, no. 21, pp. 5100-5103.
Risinger JI, Berchuck A, Kohler MF, Watson P, Lynch HT, Boyd J. Genetic Instability of Microsatellites in Endometrial Carcinoma. Cancer Research. 1993 Nov 1;53(21):5100-5103.
Risinger, John I. ; Berchuck, Andrew ; Kohler, Matthew F. ; Watson, Patrice ; Lynch, Henry T. ; Boyd, Jeff. / Genetic Instability of Microsatellites in Endometrial Carcinoma. In: Cancer Research. 1993 ; Vol. 53, No. 21. pp. 5100-5103.
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