Genetic predisposition to breast cancer

Henry T. Lynch, W. A. Albano, B. S. Danes, M. A. Layton, W. J. Kimberling, J. F. Lynch, Shih-Chuan Cheng, K. A. Costello, G. M. Mulcahy, C. A. Wagner

Research output: Contribution to journalArticle

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Abstract

Breast cancer risk factors are closely intertwined with the patient's cultural background, which may contribute to breast cancer aggregations within families. The difficult questions are: (1) does a truly hereditary breast cancer subset exist; (2) which familial aggregations are hereditary; and (3) is the hereditary form distinctive from its sporadic counterpart? These queries will be resolved once biomarkers are identified that show high sensitivity and specificity with genotype. The authors provide a review of this subject and will focus on their recent discovery of increased in vitro hyperdiploidy in cultured skin fibroblasts from patients with or at risk for hereditary breast cancer. The authors discuss findings from their study of family histories in 225 consecutively ascertained patients with verified breast cancer from the Creighton University School of Medicine Oncology Clinic. Findings consistent with an hereditary breast cancer syndrome were identified in 5% of the patients. Given the 112,000 new cases of breast cancer in the United States in 1982, the authors estimate that with a confidence coefficient of 0.95 between 2410 and 8790 of these individuals will manifest hereditary breast cancer. Specific surveillance/management programs should be geared to high-risk members of these families in which cancer yield will be predictable.

Original languageEnglish
Pages (from-to)612-622
Number of pages11
JournalCancer
Volume53
Issue number3 SUPPL.
StatePublished - 1984

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Genetic Predisposition to Disease
Breast Neoplasms
Hereditary Neoplastic Syndromes
Polyploidy
Fibroblasts
Biomarkers
Genotype
Medicine
Sensitivity and Specificity
Skin
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Albano, W. A., Danes, B. S., Layton, M. A., Kimberling, W. J., Lynch, J. F., ... Wagner, C. A. (1984). Genetic predisposition to breast cancer. Cancer, 53(3 SUPPL.), 612-622.

Genetic predisposition to breast cancer. / Lynch, Henry T.; Albano, W. A.; Danes, B. S.; Layton, M. A.; Kimberling, W. J.; Lynch, J. F.; Cheng, Shih-Chuan; Costello, K. A.; Mulcahy, G. M.; Wagner, C. A.

In: Cancer, Vol. 53, No. 3 SUPPL., 1984, p. 612-622.

Research output: Contribution to journalArticle

Lynch, HT, Albano, WA, Danes, BS, Layton, MA, Kimberling, WJ, Lynch, JF, Cheng, S-C, Costello, KA, Mulcahy, GM & Wagner, CA 1984, 'Genetic predisposition to breast cancer', Cancer, vol. 53, no. 3 SUPPL., pp. 612-622.
Lynch HT, Albano WA, Danes BS, Layton MA, Kimberling WJ, Lynch JF et al. Genetic predisposition to breast cancer. Cancer. 1984;53(3 SUPPL.):612-622.
Lynch, Henry T. ; Albano, W. A. ; Danes, B. S. ; Layton, M. A. ; Kimberling, W. J. ; Lynch, J. F. ; Cheng, Shih-Chuan ; Costello, K. A. ; Mulcahy, G. M. ; Wagner, C. A. / Genetic predisposition to breast cancer. In: Cancer. 1984 ; Vol. 53, No. 3 SUPPL. pp. 612-622.
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