Genetic/epidemiological findings in a study of smoking-associated tumors

Henry T. Lynch, Pamela R. Fain, William A. Albano, Thomas Ruma, Lynn Black, Jane Lynch, Michael Shonka

Research output: Contribution to journalArticle

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Abstract

While the etiology of bronchogenic carcinoma remains enigmatic, an expanding array of carcinogenic pollutants in interaction with host susceptibility factors has been implicated. We have studied family histories of cancer in a consecutive series of cancer patients from two university oncology clinics in Nebraska. Particular attention has been given to carcinoma of the lung and other putative smoking-associated cancers (oral cavity, esophagus, urinary bladder, pancreas). Smoking histories were obtained for relatives of an overlapping series of patients with these tumor sites. Findings revealed that, although a significant cohort effect was observed with respect to smoking habits for both relatives of lung cancer probands and for relatives of probands with other smoking-associated tumors, a corresponding trend for lung cancer frequency was observed only for relatives of lung cancer probands. This result suggests the importance of host factors in combination with environmental exposures in determining lung risk. A cohort trend for lung cancer was also apparent among relatives of breast cancer probands, but not for relatives of colon cancer probands, suggesting the possibility of an intrinsic association between carcinomas of the breast and lung. We believe that further elucidation of host factor susceptibility in lung cancer may have important etiological and preventive implications.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume6
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

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Smoking
Lung Neoplasms
Neoplasms
Lung
Breast Neoplasms
Cohort Effect
Bronchogenic Carcinoma
Mouth Neoplasms
Environmental Exposure
Colonic Neoplasms
Esophagus
Habits
Mouth
Pancreas
Urinary Bladder
Carcinoma

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Genetic/epidemiological findings in a study of smoking-associated tumors. / Lynch, Henry T.; Fain, Pamela R.; Albano, William A.; Ruma, Thomas; Black, Lynn; Lynch, Jane; Shonka, Michael.

In: Cancer Genetics and Cytogenetics, Vol. 6, No. 2, 1982, p. 163-169.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Fain, Pamela R. ; Albano, William A. ; Ruma, Thomas ; Black, Lynn ; Lynch, Jane ; Shonka, Michael. / Genetic/epidemiological findings in a study of smoking-associated tumors. In: Cancer Genetics and Cytogenetics. 1982 ; Vol. 6, No. 2. pp. 163-169.
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