Genetique et maladie du sein

Translated title of the contribution: Genetics and breast disease

Henry T. Lynch, F. Lynch

Research output: Contribution to journalArticle

Abstract

Hereditary Breast Cancer (HBC) poses a major public health problem wherein about 10% of the total breast cancer burden is due to primary genetic factors. The bulk of hereditary breast cancer is extremely heterogeneous, as evidenced by at least eight to ten differing HBC syndromes, such as hereditary breast/ovarian cancer (HBOC), the Li-Fraumeni (SBLA) syndrome, Cowden's disease, Bloom's syndrome, and heterozygotes with the ataxia telangiectasia gene. This extant heterogeneity must be carefully appraised when evaluating patients at risk for HBC. Screening ang management must be melded carefully to HBC's natural history. Genetic counseling plays a crucial part in the overall management of HBC, particularly when DNA testing is under consideration.

Original languageFrench
Pages (from-to)85-89
Number of pages5
JournalSein
Volume6
Issue number2
StatePublished - Jun 20 1996
Externally publishedYes

Fingerprint

Breast Diseases
Inborn Genetic Diseases
Breast Neoplasms
Li-Fraumeni Syndrome
Hereditary Neoplastic Syndromes
Bloom Syndrome
Multiple Hamartoma Syndrome
Ataxia Telangiectasia
Genetic Counseling
Heterozygote
Natural History
Ovarian Neoplasms
Public Health
DNA
Genes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Lynch, H. T., & Lynch, F. (1996). Genetique et maladie du sein. Sein, 6(2), 85-89.

Genetique et maladie du sein. / Lynch, Henry T.; Lynch, F.

In: Sein, Vol. 6, No. 2, 20.06.1996, p. 85-89.

Research output: Contribution to journalArticle

Lynch, HT & Lynch, F 1996, 'Genetique et maladie du sein', Sein, vol. 6, no. 2, pp. 85-89.
Lynch HT, Lynch F. Genetique et maladie du sein. Sein. 1996 Jun 20;6(2):85-89.
Lynch, Henry T. ; Lynch, F. / Genetique et maladie du sein. In: Sein. 1996 ; Vol. 6, No. 2. pp. 85-89.
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