Genetics and Colon Cancer

Henry T. Lynch, Hoda Guirgis, Milton Swartz, Jane Lynch, Anne J. Krush, Arnold R. Kaplan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This is primarily a genetic study of colon cancer based upon the examination of genealogy and all histologic varieties of cancer in probands and their first-degree relatives in a retrospective study (98 colon cancer probands) and a prospective study (50 colon cancer probands) with carefully matched controls for the prospective series. Results revealed site-specific colon cancer, breast cancer, and multiple primary malignant neoplasms occurring in significant excess amongst first-degree relatives of colon cancer probands in the experimental groups when compared with those in the control group. These observations suggest that a familial factor is etiologic for colon cancer, breast cancer, and multiple primary malignancies in certain families. The mechanism may be gene transmitted, associated with a familial-occurring oncogenous virus, or other nongenetic or familial agent, or a combination of these factors.

Original languageEnglish
Pages (from-to)669-675
Number of pages7
JournalArchives of Surgery
Volume106
Issue number5
DOIs
StatePublished - 1973

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Colonic Neoplasms
Breast Neoplasms
Multiple Primary Neoplasms
Genealogy and Heraldry
Neoplasms
Retrospective Studies
Prospective Studies
Viruses
Control Groups
Genes

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Lynch, H. T., Guirgis, H., Swartz, M., Lynch, J., Krush, A. J., & Kaplan, A. R. (1973). Genetics and Colon Cancer. Archives of Surgery, 106(5), 669-675. https://doi.org/10.1001/archsurg.1973.01350170037010

Genetics and Colon Cancer. / Lynch, Henry T.; Guirgis, Hoda; Swartz, Milton; Lynch, Jane; Krush, Anne J.; Kaplan, Arnold R.

In: Archives of Surgery, Vol. 106, No. 5, 1973, p. 669-675.

Research output: Contribution to journalArticle

Lynch, HT, Guirgis, H, Swartz, M, Lynch, J, Krush, AJ & Kaplan, AR 1973, 'Genetics and Colon Cancer', Archives of Surgery, vol. 106, no. 5, pp. 669-675. https://doi.org/10.1001/archsurg.1973.01350170037010
Lynch HT, Guirgis H, Swartz M, Lynch J, Krush AJ, Kaplan AR. Genetics and Colon Cancer. Archives of Surgery. 1973;106(5):669-675. https://doi.org/10.1001/archsurg.1973.01350170037010
Lynch, Henry T. ; Guirgis, Hoda ; Swartz, Milton ; Lynch, Jane ; Krush, Anne J. ; Kaplan, Arnold R. / Genetics and Colon Cancer. In: Archives of Surgery. 1973 ; Vol. 106, No. 5. pp. 669-675.
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