Genetics, biomarkers, and control of breast cancer: A review

Henry T. Lynch, William A. Albano, John J. Heieck, Gabriel M. Mulcahy, Jane F. Lynch, Michael A. Layton, B. Shannon Danes

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

More has been written about the epidemiology of breast cancer than possibly any other form of cancer affecting mankind. However, in the face of this intense interest, only a paucity of attention has been given to the role of genetics in its etiology. This review represents an attempt by the investigators to provide a comprehensive coverage of hereditary breast cancer. Included are pertinent endogeneous and exogeneous risk factors, which in certain circumstances, may significantly influence the role of primary genetic factors. Hereditary breast cancer is heterogeneous. When discussing the subject, therefore, one must be precise relevant to the particular heterogeneous form of concern, based on differing tumor associations. It is probably not appropriate to discuss "hereditary breast cancer" without qualification of the specific hereditary breast cancer syndrome of concern; i.e., the SBLA syndrome, breast/ovarian cancer syndrome, and others. This reasoning also applies to attempts at linking biomarkers to hereditary breast cancer. Finally, in addition to ongoing discussions on the cardinal principles that associate with hereditary forms of breast cancer, its frequency, and new developments in biomarkers, we have provided surveillance/management programs that embrace those facets of the natural history of this disease.

Original languageEnglish
Pages (from-to)43-92
Number of pages50
JournalCancer Genetics and Cytogenetics
Volume13
Issue number1
DOIs
StatePublished - 1984

Fingerprint

Biomarkers
Breast Neoplasms
Hereditary Neoplastic Syndromes
Ovarian Neoplasms
Neoplasms
Epidemiology
Research Personnel

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Lynch, H. T., Albano, W. A., Heieck, J. J., Mulcahy, G. M., Lynch, J. F., Layton, M. A., & Danes, B. S. (1984). Genetics, biomarkers, and control of breast cancer: A review. Cancer Genetics and Cytogenetics, 13(1), 43-92. https://doi.org/10.1016/0165-4608(84)90087-6

Genetics, biomarkers, and control of breast cancer : A review. / Lynch, Henry T.; Albano, William A.; Heieck, John J.; Mulcahy, Gabriel M.; Lynch, Jane F.; Layton, Michael A.; Danes, B. Shannon.

In: Cancer Genetics and Cytogenetics, Vol. 13, No. 1, 1984, p. 43-92.

Research output: Contribution to journalReview article

Lynch, HT, Albano, WA, Heieck, JJ, Mulcahy, GM, Lynch, JF, Layton, MA & Danes, BS 1984, 'Genetics, biomarkers, and control of breast cancer: A review', Cancer Genetics and Cytogenetics, vol. 13, no. 1, pp. 43-92. https://doi.org/10.1016/0165-4608(84)90087-6
Lynch, Henry T. ; Albano, William A. ; Heieck, John J. ; Mulcahy, Gabriel M. ; Lynch, Jane F. ; Layton, Michael A. ; Danes, B. Shannon. / Genetics, biomarkers, and control of breast cancer : A review. In: Cancer Genetics and Cytogenetics. 1984 ; Vol. 13, No. 1. pp. 43-92.
@article{e99830944bbe40da8e080539421cc164,
title = "Genetics, biomarkers, and control of breast cancer: A review",
abstract = "More has been written about the epidemiology of breast cancer than possibly any other form of cancer affecting mankind. However, in the face of this intense interest, only a paucity of attention has been given to the role of genetics in its etiology. This review represents an attempt by the investigators to provide a comprehensive coverage of hereditary breast cancer. Included are pertinent endogeneous and exogeneous risk factors, which in certain circumstances, may significantly influence the role of primary genetic factors. Hereditary breast cancer is heterogeneous. When discussing the subject, therefore, one must be precise relevant to the particular heterogeneous form of concern, based on differing tumor associations. It is probably not appropriate to discuss {"}hereditary breast cancer{"} without qualification of the specific hereditary breast cancer syndrome of concern; i.e., the SBLA syndrome, breast/ovarian cancer syndrome, and others. This reasoning also applies to attempts at linking biomarkers to hereditary breast cancer. Finally, in addition to ongoing discussions on the cardinal principles that associate with hereditary forms of breast cancer, its frequency, and new developments in biomarkers, we have provided surveillance/management programs that embrace those facets of the natural history of this disease.",
author = "Lynch, {Henry T.} and Albano, {William A.} and Heieck, {John J.} and Mulcahy, {Gabriel M.} and Lynch, {Jane F.} and Layton, {Michael A.} and Danes, {B. Shannon}",
year = "1984",
doi = "10.1016/0165-4608(84)90087-6",
language = "English",
volume = "13",
pages = "43--92",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Genetics, biomarkers, and control of breast cancer

T2 - A review

AU - Lynch, Henry T.

AU - Albano, William A.

AU - Heieck, John J.

AU - Mulcahy, Gabriel M.

AU - Lynch, Jane F.

AU - Layton, Michael A.

AU - Danes, B. Shannon

PY - 1984

Y1 - 1984

N2 - More has been written about the epidemiology of breast cancer than possibly any other form of cancer affecting mankind. However, in the face of this intense interest, only a paucity of attention has been given to the role of genetics in its etiology. This review represents an attempt by the investigators to provide a comprehensive coverage of hereditary breast cancer. Included are pertinent endogeneous and exogeneous risk factors, which in certain circumstances, may significantly influence the role of primary genetic factors. Hereditary breast cancer is heterogeneous. When discussing the subject, therefore, one must be precise relevant to the particular heterogeneous form of concern, based on differing tumor associations. It is probably not appropriate to discuss "hereditary breast cancer" without qualification of the specific hereditary breast cancer syndrome of concern; i.e., the SBLA syndrome, breast/ovarian cancer syndrome, and others. This reasoning also applies to attempts at linking biomarkers to hereditary breast cancer. Finally, in addition to ongoing discussions on the cardinal principles that associate with hereditary forms of breast cancer, its frequency, and new developments in biomarkers, we have provided surveillance/management programs that embrace those facets of the natural history of this disease.

AB - More has been written about the epidemiology of breast cancer than possibly any other form of cancer affecting mankind. However, in the face of this intense interest, only a paucity of attention has been given to the role of genetics in its etiology. This review represents an attempt by the investigators to provide a comprehensive coverage of hereditary breast cancer. Included are pertinent endogeneous and exogeneous risk factors, which in certain circumstances, may significantly influence the role of primary genetic factors. Hereditary breast cancer is heterogeneous. When discussing the subject, therefore, one must be precise relevant to the particular heterogeneous form of concern, based on differing tumor associations. It is probably not appropriate to discuss "hereditary breast cancer" without qualification of the specific hereditary breast cancer syndrome of concern; i.e., the SBLA syndrome, breast/ovarian cancer syndrome, and others. This reasoning also applies to attempts at linking biomarkers to hereditary breast cancer. Finally, in addition to ongoing discussions on the cardinal principles that associate with hereditary forms of breast cancer, its frequency, and new developments in biomarkers, we have provided surveillance/management programs that embrace those facets of the natural history of this disease.

UR - http://www.scopus.com/inward/record.url?scp=0021284973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021284973&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(84)90087-6

DO - 10.1016/0165-4608(84)90087-6

M3 - Review article

C2 - 6380704

AN - SCOPUS:0021284973

VL - 13

SP - 43

EP - 92

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -