Genetics of colonic cancer

Henry T. Lynch, Jane F. Lynch

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Research in hereditary forms of colorectal cancer (CRC) has increased almost logarithmically thanks in a major way to momentous discoveries in molecular genetics during the past decade. Between 10 and 20% of the total CRC burden is due to Mendelian-inherited CRC syndromes. The paradigm for hereditary CRC is familial adenomatous polyposis (FAP), wherein the APC germ-line mutation has been identified. This has contributed to the elucidation of genomic and clinical heterogeneity within the syndrome, wherein an attenuated form of FAP has been identified as a result of intragenic mutations within this large APC gene. The most common form of hereditary CRC is hereditary nonpolyposis colorectal cancer (HNPCC). Several mutator genes, namely hMSH2, hMLH1, hPMS1, hPMS2 and, more recently, hMSH6/GTBP, have been identified. These molecular genetic discoveries are providing new insights into the pathogenesis of CRC. Individuals within these kindreds who are harbingers of these germ-line mutations will benefit from screening and, one day, chemoprevention.

Original languageEnglish
Pages (from-to)481-492
Number of pages12
JournalDigestion
Volume59
Issue number5
DOIs
StatePublished - Aug 1998

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Colonic Neoplasms
Colorectal Neoplasms
Germ-Line Mutation
Molecular Biology
APC Genes
Hereditary Nonpolyposis Colorectal Neoplasms
Adenomatous Polyposis Coli
Chemoprevention
Mutation
Research
Genes

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Genetics of colonic cancer. / Lynch, Henry T.; Lynch, Jane F.

In: Digestion, Vol. 59, No. 5, 08.1998, p. 481-492.

Research output: Contribution to journalReview article

Lynch, HT & Lynch, JF 1998, 'Genetics of colonic cancer', Digestion, vol. 59, no. 5, pp. 481-492. https://doi.org/10.1159/000007525
Lynch, Henry T. ; Lynch, Jane F. / Genetics of colonic cancer. In: Digestion. 1998 ; Vol. 59, No. 5. pp. 481-492.
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