Abstract
Two operational subdivisions of hereditary colorectal cancer susceptibility are those with and those without premalignant adenomatous colonic polyp expression. In both of these subdivisions, reliable biomarkers of gene carriage would be of value in patient management as we have previously emphasized. Consideration must also be given to the familial (hereditary) occurrence of inflammatory bowel diseases associated with colorectal cancer susceptibility. The occurrence of rectal cancer should therefore alert the physician to investigate the possibility of a significant family medical history in order to fully elucidate the genetic heterogeneity of susceptibility to this disease. Clinicians should also be alert to the possibility of extracolonic malignancies where probable genetic colorectal cancer susceptibility is evident. Whenever possible, all potential biomarkers should be investigated to aid in the definition of genetic heterogeneity.
| Original language | English |
|---|---|
| Pages (from-to) | 1-15 |
| Number of pages | 15 |
| Journal | Bulletin du Cancer |
| Volume | 71 |
| Issue number | 1 |
| State | Published - 1984 |
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All Science Journal Classification (ASJC) codes
- Oncology
Cite this
Genetics of rectal cancer. / Lynch, Henry T.; Schuelke, G. S.; Lynch, J. F.
In: Bulletin du Cancer, Vol. 71, No. 1, 1984, p. 1-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetics of rectal cancer
AU - Lynch, Henry T.
AU - Schuelke, G. S.
AU - Lynch, J. F.
PY - 1984
Y1 - 1984
N2 - Two operational subdivisions of hereditary colorectal cancer susceptibility are those with and those without premalignant adenomatous colonic polyp expression. In both of these subdivisions, reliable biomarkers of gene carriage would be of value in patient management as we have previously emphasized. Consideration must also be given to the familial (hereditary) occurrence of inflammatory bowel diseases associated with colorectal cancer susceptibility. The occurrence of rectal cancer should therefore alert the physician to investigate the possibility of a significant family medical history in order to fully elucidate the genetic heterogeneity of susceptibility to this disease. Clinicians should also be alert to the possibility of extracolonic malignancies where probable genetic colorectal cancer susceptibility is evident. Whenever possible, all potential biomarkers should be investigated to aid in the definition of genetic heterogeneity.
AB - Two operational subdivisions of hereditary colorectal cancer susceptibility are those with and those without premalignant adenomatous colonic polyp expression. In both of these subdivisions, reliable biomarkers of gene carriage would be of value in patient management as we have previously emphasized. Consideration must also be given to the familial (hereditary) occurrence of inflammatory bowel diseases associated with colorectal cancer susceptibility. The occurrence of rectal cancer should therefore alert the physician to investigate the possibility of a significant family medical history in order to fully elucidate the genetic heterogeneity of susceptibility to this disease. Clinicians should also be alert to the possibility of extracolonic malignancies where probable genetic colorectal cancer susceptibility is evident. Whenever possible, all potential biomarkers should be investigated to aid in the definition of genetic heterogeneity.
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M3 - Article
C2 - 6713110
AN - SCOPUS:0021254128
VL - 71
SP - 1
EP - 15
JO - Bulletin du Cancer
JF - Bulletin du Cancer
SN - 0007-4551
IS - 1
ER -