Genetics of rectal cancer

Henry T. Lynch, G. S. Schuelke, J. F. Lynch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two operational subdivisions of hereditary colorectal cancer susceptibility are those with and those without premalignant adenomatous colonic polyp expression. In both of these subdivisions, reliable biomarkers of gene carriage would be of value in patient management as we have previously emphasized. Consideration must also be given to the familial (hereditary) occurrence of inflammatory bowel diseases associated with colorectal cancer susceptibility. The occurrence of rectal cancer should therefore alert the physician to investigate the possibility of a significant family medical history in order to fully elucidate the genetic heterogeneity of susceptibility to this disease. Clinicians should also be alert to the possibility of extracolonic malignancies where probable genetic colorectal cancer susceptibility is evident. Whenever possible, all potential biomarkers should be investigated to aid in the definition of genetic heterogeneity.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalBulletin du Cancer
Volume71
Issue number1
StatePublished - 1984

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Rectal Neoplasms
Colorectal Neoplasms
Genetic Heterogeneity
Medical History Taking
Biomarkers
Colonic Polyps
Adenomatous Polyps
Genetic Predisposition to Disease
Inflammatory Bowel Diseases
Physicians
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Lynch, H. T., Schuelke, G. S., & Lynch, J. F. (1984). Genetics of rectal cancer. Bulletin du Cancer, 71(1), 1-15.

Genetics of rectal cancer. / Lynch, Henry T.; Schuelke, G. S.; Lynch, J. F.

In: Bulletin du Cancer, Vol. 71, No. 1, 1984, p. 1-15.

Research output: Contribution to journalArticle

Lynch, HT, Schuelke, GS & Lynch, JF 1984, 'Genetics of rectal cancer', Bulletin du Cancer, vol. 71, no. 1, pp. 1-15.
Lynch HT, Schuelke GS, Lynch JF. Genetics of rectal cancer. Bulletin du Cancer. 1984;71(1):1-15.
Lynch, Henry T. ; Schuelke, G. S. ; Lynch, J. F. / Genetics of rectal cancer. In: Bulletin du Cancer. 1984 ; Vol. 71, No. 1. pp. 1-15.
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