Genetics of rectal cancer

H. T. Lynch, G. S. Schuelke, J. F. Lynch

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Two operational subdivisions of hereditary colorectal cancer susceptibility are those with and those without premalignant adenomatous colonic polyp expression. In both of these subdivisions, reliable biomarkers of gene carriage would be of value in patient management as we have previously emphasized. Consideration must also be given to the familial (hereditary) occurrence of inflammatory bowel diseases associated with colorectal cancer susceptibility. The occurrence of rectal cancer should therefore alert the physician to investigate the possibility of a significant family medical history in order to fully elucidate the genetic heterogeneity of susceptibility to this disease. Clinicians should also be alert to the possibility of extracolonic malignancies where probable genetic colorectal cancer susceptibility is evident. Whenever possible, all potential biomarkers should be investigated to aid in the definition of genetic heterogeneity.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalBulletin du Cancer
Issue number1
StatePublished - Jan 1 1984

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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