Genome-wide copy number variation association study suggested VPS13B gene for osteoporosis in Caucasians

F. Y. Deng, L. J. Zhao, Y. F. Pei, B. Y. Sha, X. G. Liu, H. Yan, L. Wang, T. L. Yang, R. R. Recker, C. J. Papasian, H. W. Deng

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Abstract

Summary Osteoporotic fracture (OF) is a serious outcome of osteoporosis. Important risk factors for OF include reduced bone mineral density and unstable bone structure. This genome-wide copy number variation association study suggested VPS13B gene for osteoporosis in Caucasians. Introduction Bone mineral density (BMD) and femoral neck cross-sectional geometric parameters (FNCSGPs) are under strong genetic control. DNA copy number variation (CNV) is an important source of genetic diversity for human diseases. This study aims to identify CNVs associated with BMD and FNCSGPs. Methods Genome-wide CNV association analyses were conducted in 1,000 unrelated Caucasian subjects for BMD at the spine, hip, femoral neck, and for three FNCSGPs -cortical thickness (CT), cross-section area (CSA), and buckling ratio (BR). BMD was measured by dual energy X-ray absorptiometry (DEXA). CT, CSA, and BR were estimated using DEXA measurements. Affymetrix 500K arrays and copy number analysis tool was used to identify CNVs. Results A CNV in VPS13B gene was significantly associated with spine, hip and FN BMDs, and CT, CSA, and BR (p

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalOsteoporosis International
Volume21
Issue number4
DOIs
StatePublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

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    Deng, F. Y., Zhao, L. J., Pei, Y. F., Sha, B. Y., Liu, X. G., Yan, H., Wang, L., Yang, T. L., Recker, R. R., Papasian, C. J., & Deng, H. W. (2010). Genome-wide copy number variation association study suggested VPS13B gene for osteoporosis in Caucasians. Osteoporosis International, 21(4), 579-587. https://doi.org/10.1007/s00198-009-0998-7