Genotype/Phenotype of Familial Pancreatic Cancer

Randall E. Brand, Henry T. Lynch

Research output: Contribution to journal › Review article

12 Citations (Scopus)

Abstract

The challenges in defining pancreatic cancer are great because of our recognition that even sporadic cancer cases are likely at the end of a spectrum, where the individual genetic etiologies are more difficult to identify [24]. A polygenic model that takes into account nongenetic risk factors, most notably smoking, seems to be most appropriate for pancreatic cancer. With few exceptions (eg, hereditary pancreatitis), Mendelian inherited pancreatic cancer-prone syndromes involve a variety of cancers of different anatomic sites, wherein their phenotypic and genotypic heterogeneity may be extant.

Original languageEnglish
Pages (from-to)405-415
Number of pages11
JournalEndocrinology and Metabolism Clinics of North America
Volume35
Issue number2
DOIs
StatePublished - Jun 2006

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Pancreatic Neoplasms
Genotype
Phenotype
Neoplasms
Smoking

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Biochemistry

Cite this

Genotype/Phenotype of Familial Pancreatic Cancer. / Brand, Randall E.; Lynch, Henry T.

In: Endocrinology and Metabolism Clinics of North America, Vol. 35, No. 2, 06.2006, p. 405-415.

Research output: Contribution to journal › Review article

Brand, RE & Lynch, HT 2006, 'Genotype/Phenotype of Familial Pancreatic Cancer', Endocrinology and Metabolism Clinics of North America, vol. 35, no. 2, pp. 405-415. https://doi.org/10.1016/j.ecl.2006.02.015
Brand RE, Lynch HT. Genotype/Phenotype of Familial Pancreatic Cancer. Endocrinology and Metabolism Clinics of North America. 2006 Jun;35(2):405-415. https://doi.org/10.1016/j.ecl.2006.02.015
Brand, Randall E. ; Lynch, Henry T. / Genotype/Phenotype of Familial Pancreatic Cancer. In: Endocrinology and Metabolism Clinics of North America. 2006 ; Vol. 35, No. 2. pp. 405-415.
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