Genotype/Phenotype of Familial Pancreatic Cancer

Randall E. Brand, Henry T. Lynch

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

The challenges in defining pancreatic cancer are great because of our recognition that even sporadic cancer cases are likely at the end of a spectrum, where the individual genetic etiologies are more difficult to identify [24]. A polygenic model that takes into account nongenetic risk factors, most notably smoking, seems to be most appropriate for pancreatic cancer. With few exceptions (eg, hereditary pancreatitis), Mendelian inherited pancreatic cancer-prone syndromes involve a variety of cancers of different anatomic sites, wherein their phenotypic and genotypic heterogeneity may be extant.

Original languageEnglish (US)
Pages (from-to)405-415
Number of pages11
JournalEndocrinology and Metabolism Clinics of North America
Volume35
Issue number2
DOIs
StatePublished - Jun 2006

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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