Abstract
The challenges in defining pancreatic cancer are great because of our recognition that even sporadic cancer cases are likely at the end of a spectrum, where the individual genetic etiologies are more difficult to identify [24]. A polygenic model that takes into account nongenetic risk factors, most notably smoking, seems to be most appropriate for pancreatic cancer. With few exceptions (eg, hereditary pancreatitis), Mendelian inherited pancreatic cancer-prone syndromes involve a variety of cancers of different anatomic sites, wherein their phenotypic and genotypic heterogeneity may be extant.
| Original language | English |
|---|---|
| Pages (from-to) | 405-415 |
| Number of pages | 11 |
| Journal | Endocrinology and Metabolism Clinics of North America |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2006 |
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All Science Journal Classification (ASJC) codes
- Endocrinology
- Biochemistry
Cite this
Genotype/Phenotype of Familial Pancreatic Cancer. / Brand, Randall E.; Lynch, Henry T.
In: Endocrinology and Metabolism Clinics of North America, Vol. 35, No. 2, 06.2006, p. 405-415.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Genotype/Phenotype of Familial Pancreatic Cancer
AU - Brand, Randall E.
AU - Lynch, Henry T.
PY - 2006/6
Y1 - 2006/6
N2 - The challenges in defining pancreatic cancer are great because of our recognition that even sporadic cancer cases are likely at the end of a spectrum, where the individual genetic etiologies are more difficult to identify [24]. A polygenic model that takes into account nongenetic risk factors, most notably smoking, seems to be most appropriate for pancreatic cancer. With few exceptions (eg, hereditary pancreatitis), Mendelian inherited pancreatic cancer-prone syndromes involve a variety of cancers of different anatomic sites, wherein their phenotypic and genotypic heterogeneity may be extant.
AB - The challenges in defining pancreatic cancer are great because of our recognition that even sporadic cancer cases are likely at the end of a spectrum, where the individual genetic etiologies are more difficult to identify [24]. A polygenic model that takes into account nongenetic risk factors, most notably smoking, seems to be most appropriate for pancreatic cancer. With few exceptions (eg, hereditary pancreatitis), Mendelian inherited pancreatic cancer-prone syndromes involve a variety of cancers of different anatomic sites, wherein their phenotypic and genotypic heterogeneity may be extant.
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UR - http://www.scopus.com/inward/citedby.url?scp=33646500104&partnerID=8YFLogxK
U2 - 10.1016/j.ecl.2006.02.015
DO - 10.1016/j.ecl.2006.02.015
M3 - Review article
C2 - 16632102
AN - SCOPUS:33646500104
VL - 35
SP - 405
EP - 415
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
SN - 0889-8529
IS - 2
ER -