Abstract
The challenges in defining pancreatic cancer are great because of our recognition that even sporadic cancer cases are likely at the end of a spectrum, where the individual genetic etiologies are more difficult to identify [24]. A polygenic model that takes into account nongenetic risk factors, most notably smoking, seems to be most appropriate for pancreatic cancer. With few exceptions (eg, hereditary pancreatitis), Mendelian inherited pancreatic cancer-prone syndromes involve a variety of cancers of different anatomic sites, wherein their phenotypic and genotypic heterogeneity may be extant.
Original language | English (US) |
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Pages (from-to) | 405-415 |
Number of pages | 11 |
Journal | Endocrinology and Metabolism Clinics of North America |
Volume | 35 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2006 |
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology