Genotype/Phenotype of Familial Pancreatic Cancer

Randall E. Brand, Henry T. Lynch

12 Scopus citations

Abstract

The challenges in defining pancreatic cancer are great because of our recognition that even sporadic cancer cases are likely at the end of a spectrum, where the individual genetic etiologies are more difficult to identify [24]. A polygenic model that takes into account nongenetic risk factors, most notably smoking, seems to be most appropriate for pancreatic cancer. With few exceptions (eg, hereditary pancreatitis), Mendelian inherited pancreatic cancer-prone syndromes involve a variety of cancers of different anatomic sites, wherein their phenotypic and genotypic heterogeneity may be extant.

Original languageEnglish
Pages (from-to)405-415
Number of pages11
JournalEndocrinology and Metabolism Clinics of North America
Volume35
Issue number2
DOIs
Publication statusPublished - Jun 2006

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All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Biochemistry

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