Growth hormone: the effect on skeletal renewal in the adult dog I. Morphometric studies

W. H. Harris; R. P. Heaney; J. Jowsey; J. Cockin; C. Akins; J. Graham; E. H. Weinberg

doi:10.1007/BF02012530

Growth hormone: the effect on skeletal renewal in the adult dog I. Morphometric studies

W. H. Harris, R. P. Heaney, J. Jowsey, J. Cockin, C. Akins, J. Graham, E. H. Weinberg

Department of Medicine

Research output: Contribution to journal › Article

56 Scopus citations

Abstract

In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteal resorption was decreased. Intracortical resorption was increased but intracortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographically. Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.

Original language	English (US)
Pages (from-to)	1-13
Number of pages	13
Journal	Calcified Tissue Research
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/BF02012530
State	Published - Dec 1 1972

Fingerprint

All Science Journal Classification (ASJC) codes

Endocrinology

Cite this

Harris, W. H., Heaney, R. P., Jowsey, J., Cockin, J., Akins, C., Graham, J., & Weinberg, E. H. (1972). Growth hormone: the effect on skeletal renewal in the adult dog I. Morphometric studies. Calcified Tissue Research, 10(1), 1-13. https://doi.org/10.1007/BF02012530

@article{9a19354221ca4e95a867a13bd138d01b,

title = "Growth hormone: the effect on skeletal renewal in the adult dog I. Morphometric studies",

abstract = "In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteal resorption was decreased. Intracortical resorption was increased but intracortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographically. Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.",

author = "Harris, {W. H.} and Heaney, {R. P.} and J. Jowsey and J. Cockin and C. Akins and J. Graham and Weinberg, {E. H.}",

year = "1972",

month = dec

day = "1",

doi = "10.1007/BF02012530",

language = "English (US)",

volume = "10",

pages = "1--13",

journal = "Calcified Tissue International",

issn = "0171-967X",

publisher = "Springer New York",

number = "1",

}

TY - JOUR

T1 - Growth hormone

T2 - the effect on skeletal renewal in the adult dog I. Morphometric studies

AU - Harris, W. H.

AU - Heaney, R. P.

AU - Jowsey, J.

AU - Cockin, J.

AU - Akins, C.

AU - Graham, J.

AU - Weinberg, E. H.

PY - 1972/12/1

Y1 - 1972/12/1

N2 - In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteal resorption was decreased. Intracortical resorption was increased but intracortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographically. Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.

AB - In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteal resorption was decreased. Intracortical resorption was increased but intracortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographically. Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.

UR - http://www.scopus.com/inward/record.url?scp=0015272094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015272094&partnerID=8YFLogxK

U2 - 10.1007/BF02012530

DO - 10.1007/BF02012530

M3 - Article

C2 - 4626613

AN - SCOPUS:0015272094

VL - 10

SP - 1

EP - 13

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 1

ER -

Access to Document

10.1007/BF02012530