Abstract
In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteal resorption was decreased. Intracortical resorption was increased but intracortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographically. Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.
| Original language | English |
|---|---|
| Pages (from-to) | 1-13 |
| Number of pages | 13 |
| Journal | Calcified Tissue Research |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1972 |
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All Science Journal Classification (ASJC) codes
- Endocrinology
- Medicine(all)
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Growth hormone : the effect on skeletal renewal in the adult dog I. Morphometric studies. / Harris, W. H.; Heaney, R. P.; Jowsey, J.; Cockin, J.; Akins, C.; Graham, J.; Weinberg, E. H.
In: Calcified Tissue Research, Vol. 10, No. 1, 12.1972, p. 1-13.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth hormone
T2 - the effect on skeletal renewal in the adult dog I. Morphometric studies
AU - Harris, W. H.
AU - Heaney, R. P.
AU - Jowsey, J.
AU - Cockin, J.
AU - Akins, C.
AU - Graham, J.
AU - Weinberg, E. H.
PY - 1972/12
Y1 - 1972/12
N2 - In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteal resorption was decreased. Intracortical resorption was increased but intracortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographically. Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.
AB - In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteal resorption was decreased. Intracortical resorption was increased but intracortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographically. Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.
UR - http://www.scopus.com/inward/record.url?scp=0015272094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015272094&partnerID=8YFLogxK
U2 - 10.1007/BF02012530
DO - 10.1007/BF02012530
M3 - Article
C2 - 4626613
AN - SCOPUS:0015272094
VL - 10
SP - 1
EP - 13
JO - Calcified Tissue International
JF - Calcified Tissue International
SN - 0171-967X
IS - 1
ER -