Guidelines for optimizing design and analysis of clinical studies of nutrient effects

Robert P. Heaney

Research output: Contribution to journalArticle

152 Scopus citations

Abstract

Presented here is a system to standardize clinical studies of nutrient effects, using nutrient-specific physiological criteria. These guidelines are based mainly on analysis of the typical sigmoid curve of biological response to nutrients and are intended for design, interpretation, and pooling of studies of nutrient effects. Five rules have been articulated for individual studies of nutrients, and six for systematic reviews and/or meta-analyses.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalNutrition Reviews
Volume72
Issue number1
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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