Guidelines for optimizing design and analysis of clinical studies of nutrient effects

Robert P. Heaney

Research output: Contribution to journal › Article

121 Citations (Scopus)

Abstract

Presented here is a system to standardize clinical studies of nutrient effects, using nutrient-specific physiological criteria. These guidelines are based mainly on analysis of the typical sigmoid curve of biological response to nutrients and are intended for design, interpretation, and pooling of studies of nutrient effects. Five rules have been articulated for individual studies of nutrients, and six for systematic reviews and/or meta-analyses.

Original languageEnglish
Pages (from-to)48-54
Number of pages7
JournalNutrition Reviews
Volume72
Issue number1
DOIs
StatePublished - Jan 2014

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Guidelines
Food
Sigmoid Colon
Meta-Analysis
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Guidelines for optimizing design and analysis of clinical studies of nutrient effects. / Heaney, Robert P.

In: Nutrition Reviews, Vol. 72, No. 1, 01.2014, p. 48-54.

Research output: Contribution to journal › Article

Heaney, RP 2014, 'Guidelines for optimizing design and analysis of clinical studies of nutrient effects', Nutrition Reviews, vol. 72, no. 1, pp. 48-54. https://doi.org/10.1111/nure.12090
Heaney RP. Guidelines for optimizing design and analysis of clinical studies of nutrient effects. Nutrition Reviews. 2014 Jan;72(1):48-54. https://doi.org/10.1111/nure.12090
Heaney, Robert P. / Guidelines for optimizing design and analysis of clinical studies of nutrient effects. In: Nutrition Reviews. 2014 ; Vol. 72, No. 1. pp. 48-54.
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