Guidelines for optimizing design and analysis of clinical studies of nutrient effects

Robert P. Heaney

doi:10.1111/nure.12090

Guidelines for optimizing design and analysis of clinical studies of nutrient effects

Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Article › peer-review

168 Scopus citations

Abstract

Presented here is a system to standardize clinical studies of nutrient effects, using nutrient-specific physiological criteria. These guidelines are based mainly on analysis of the typical sigmoid curve of biological response to nutrients and are intended for design, interpretation, and pooling of studies of nutrient effects. Five rules have been articulated for individual studies of nutrients, and six for systematic reviews and/or meta-analyses.

Original language	English (US)
Pages (from-to)	48-54
Number of pages	7
Journal	Nutrition Reviews
Volume	72
Issue number	1
DOIs	https://doi.org/10.1111/nure.12090
State	Published - Jan 1 2014

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1111/nure.12090

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