TY - JOUR
T1 - Has Vitamin D had its "time in the sun" for melanoma?
AU - Huerter, Christopher
AU - Vaudreuil, Adam
AU - Agrawal, Devendra K.
AU - Nguyen, Austin Huy
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Growing evidence suggests a pivotal role for Vitamin D in cancers, particularly melanoma. The broad immunologic effects of Vitamin D and its signaling axis make for a complex interplay between tumor cells and the immune system. Preclinical evidence suggests Vitamin D to have protective effects in melanoma oncogenesis and progression, creating a potential role for Vitamin D supplementation in cancer prevention and/or adjuvant therapy. In this commentary, the authors highlight studies of Vitamin D in melanoma with clinical implications and call for large clinical trials to definitively determine the role of supplementation in patients to prevent and help treat melanoma.
AB - Growing evidence suggests a pivotal role for Vitamin D in cancers, particularly melanoma. The broad immunologic effects of Vitamin D and its signaling axis make for a complex interplay between tumor cells and the immune system. Preclinical evidence suggests Vitamin D to have protective effects in melanoma oncogenesis and progression, creating a potential role for Vitamin D supplementation in cancer prevention and/or adjuvant therapy. In this commentary, the authors highlight studies of Vitamin D in melanoma with clinical implications and call for large clinical trials to definitively determine the role of supplementation in patients to prevent and help treat melanoma.
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M3 - Review article
AN - SCOPUS:85006493435
VL - 9
SP - 11
EP - 12
JO - Journal of Clinical and Aesthetic Dermatology
JF - Journal of Clinical and Aesthetic Dermatology
SN - 1941-2789
IS - 12
ER -