Heart-specific autoantibodies following murine Coxsackievirus B3 myocarditis

L. J. Wolfgram, Kirk Beisel, N. R. Rose

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.

Original languageEnglish
Pages (from-to)1112-1121
Number of pages10
JournalJournal of Experimental Medicine
Volume161
Issue number5
StatePublished - 1985
Externally publishedYes

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Enterovirus
Myocarditis
Autoimmunity
Autoantibodies
Antibodies
Indirect Fluorescent Antibody Technique
Skeletal Muscle
Animal Models
Kidney
Serum

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Heart-specific autoantibodies following murine Coxsackievirus B3 myocarditis. / Wolfgram, L. J.; Beisel, Kirk; Rose, N. R.

In: Journal of Experimental Medicine, Vol. 161, No. 5, 1985, p. 1112-1121.

Research output: Contribution to journalArticle

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