Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis

Luanne J. Wolfgram, Kirk W. Beisel, Noel R. Rose

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.

Original languageEnglish (US)
Pages (from-to)1112-1121
Number of pages10
JournalJournal of Experimental Medicine
Volume161
Issue number5
DOIs
StatePublished - May 1 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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