Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis

Luanne J. Wolfgram, Kirk W. Beisel, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.

Original languageEnglish (US)
Pages (from-to)1112-1121
Number of pages10
JournalJournal of Experimental Medicine
Issue number5
StatePublished - May 1 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis'. Together they form a unique fingerprint.

Cite this