Abstract
Hematopoietic stem and progenitor cells contribute to allergic inflammation. Pro-inflammatory cytokines that are generated following allergen challenge can impact the differentiation of hematopoietic progenitor cells leading to increased production of effector cells such as eosinophils and basophils, which are key cells involved in the pathogenesis of allergic airway inflammation. Homing of stem cells to the lungs is associated with inflammatory and remodeling changes in asthmatics. Factors that modulate the differentiation and increased migration of stem cells to the site of inflammation in asthma remain to be defined. Stem cells can mature at the site of inflammation in response to inflammatory mediators and other components in the milieu. While the available data suggest that hematopoietic cells traffic to target tissues, the molecular factors underlying in situ differentiation have yet to be specified. Here, we critically evaluate the potential role of hematopoietic progenitors in contributing to the increased immune cell infiltrate in allergic asthma and the factors that drive their differentiation.
| Original language | English |
|---|---|
| Article number | Article 428 |
| Journal | Frontiers in Immunology |
| Volume | 4 |
| Issue number | DEC |
| DOIs | |
| State | Published - 2013 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Allergy
Cite this
Hematopoietic stem and progenitor cells in inflammation and allergy. / Fischer, Kimberly D.; Agrawal, Devendra K.
In: Frontiers in Immunology, Vol. 4, No. DEC, Article 428, 2013.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hematopoietic stem and progenitor cells in inflammation and allergy
AU - Fischer, Kimberly D.
AU - Agrawal, Devendra K.
PY - 2013
Y1 - 2013
N2 - Hematopoietic stem and progenitor cells contribute to allergic inflammation. Pro-inflammatory cytokines that are generated following allergen challenge can impact the differentiation of hematopoietic progenitor cells leading to increased production of effector cells such as eosinophils and basophils, which are key cells involved in the pathogenesis of allergic airway inflammation. Homing of stem cells to the lungs is associated with inflammatory and remodeling changes in asthmatics. Factors that modulate the differentiation and increased migration of stem cells to the site of inflammation in asthma remain to be defined. Stem cells can mature at the site of inflammation in response to inflammatory mediators and other components in the milieu. While the available data suggest that hematopoietic cells traffic to target tissues, the molecular factors underlying in situ differentiation have yet to be specified. Here, we critically evaluate the potential role of hematopoietic progenitors in contributing to the increased immune cell infiltrate in allergic asthma and the factors that drive their differentiation.
AB - Hematopoietic stem and progenitor cells contribute to allergic inflammation. Pro-inflammatory cytokines that are generated following allergen challenge can impact the differentiation of hematopoietic progenitor cells leading to increased production of effector cells such as eosinophils and basophils, which are key cells involved in the pathogenesis of allergic airway inflammation. Homing of stem cells to the lungs is associated with inflammatory and remodeling changes in asthmatics. Factors that modulate the differentiation and increased migration of stem cells to the site of inflammation in asthma remain to be defined. Stem cells can mature at the site of inflammation in response to inflammatory mediators and other components in the milieu. While the available data suggest that hematopoietic cells traffic to target tissues, the molecular factors underlying in situ differentiation have yet to be specified. Here, we critically evaluate the potential role of hematopoietic progenitors in contributing to the increased immune cell infiltrate in allergic asthma and the factors that drive their differentiation.
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UR - http://www.scopus.com/inward/citedby.url?scp=84892145665&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2013.00428
DO - 10.3389/fimmu.2013.00428
M3 - Review article
AN - SCOPUS:84892145665
VL - 4
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - DEC
M1 - Article 428
ER -