Hemodynamic patterns of survivors and nonsurvivors during high risk elective surgical operations

William C. Shoemaker, Charles C J Wo, Duraiyah Thangathurai, George Velmahos, Howard Belzberg, Juan A. Asensio, Demetrios Demetriades

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Postoperative survivors' and nonsurvivors' hemodynamic and oxygen transport patterns have been extensively studied, and the early postoperative circulatory events leading to organ failures and death have been documented. Outcome was improved when potentially lethal circulatory patterns were treated during the early(the first 8-12 hours) postoperative period; but after the appearance of organ failure, reversal of nonsurvival patterns did not improve the outcome. The purpose of this study was to describe prospectively intraoperative circulatory deficiencies that precede shock, organ failures, and death. The ultimate aim was to elucidate nonsurvivor patterns at the earliest possible time to develop more effective preventive strategies for lethal organ failures. This approach is based on the assumption that it is easier and more effective to prevent the initiators of shock, such as hypovolemia, hypoxemia, poor tissue perfusion, and tissue hypoxia, than to treat the mediators of organ failure, such as cytokines, antigens, eicosinoids, and heat shock proteins. We monitored 356 high risk elective surgical patients with preoperative and iutraoperative hemodynamic monitoring by the pulmonary artery (PA) thermodilution catheter. The conventionally monitored mean arterial pressure and heart rate remained in the normal range in both groups; the nonsurvivor pattern included decreased cardiac index, stroke index, stroke work, oxygen delivery, and oxygen consumption. Low oxygen consumption was partly compensated by increased oxygen extraction rates, and arterial pressures were maintained by increasing systemic vascular resistance. The early temporal pattern of nonsurvivors' changes were similar to those described during the postoperative period that preceded development of organ failure and death. This suggests that lethal circulatory dysfunctions may begin during the intraoperative period but become more apparent before and after organs fail during later postoperative stages.

Original languageEnglish
Pages (from-to)1264-1271
Number of pages8
JournalWorld Journal of Surgery
Volume23
Issue number12
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Survivors
Hemodynamics
Oxygen
Postoperative Period
Oxygen Consumption
Shock
Arterial Pressure
Stroke
Intraoperative Period
Thermodilution
Hypovolemia
Heat-Shock Proteins
Vascular Resistance
Pulmonary Artery
Reference Values
Catheters
Perfusion
Heart Rate
Cytokines
Antigens

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Shoemaker, W. C., Wo, C. C. J., Thangathurai, D., Velmahos, G., Belzberg, H., Asensio, J. A., & Demetriades, D. (1999). Hemodynamic patterns of survivors and nonsurvivors during high risk elective surgical operations. World Journal of Surgery, 23(12), 1264-1271. https://doi.org/10.1007/s002689900660

Hemodynamic patterns of survivors and nonsurvivors during high risk elective surgical operations. / Shoemaker, William C.; Wo, Charles C J; Thangathurai, Duraiyah; Velmahos, George; Belzberg, Howard; Asensio, Juan A.; Demetriades, Demetrios.

In: World Journal of Surgery, Vol. 23, No. 12, 1999, p. 1264-1271.

Research output: Contribution to journalArticle

Shoemaker, WC, Wo, CCJ, Thangathurai, D, Velmahos, G, Belzberg, H, Asensio, JA & Demetriades, D 1999, 'Hemodynamic patterns of survivors and nonsurvivors during high risk elective surgical operations', World Journal of Surgery, vol. 23, no. 12, pp. 1264-1271. https://doi.org/10.1007/s002689900660
Shoemaker, William C. ; Wo, Charles C J ; Thangathurai, Duraiyah ; Velmahos, George ; Belzberg, Howard ; Asensio, Juan A. ; Demetriades, Demetrios. / Hemodynamic patterns of survivors and nonsurvivors during high risk elective surgical operations. In: World Journal of Surgery. 1999 ; Vol. 23, No. 12. pp. 1264-1271.
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