Hemostatic implications of endothelial cell apoptosis in obstructive sleep apnea

Ali A. El Solh, Morohunfolu E. Akinnusi, Ilya Berim, A. Misha Peter, Linda L. Paasch, Kristie R. Szarpa

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Patients with obstructive sleep apnea (OSA) are at increased risk of atherothrombosis independent of the Framingham risk factors. Studies on hemostasis factors in OSA are scarce and inconsistent. We sought to understand the variation in atherothrombotic propensity as a function of apoptotic circulating endothelial cells (CECs) in OSA by investigating the relationship between CEC apoptosis and plasma levels of hemostatic factors tissue factor (TF) and von Willebrand Factor (vWF) in apneic subjects. Apoptotic CECs were detected by flow cytometry in 35 male subjects free of cardiovascular diseases (AHI range 8-43) and 12 healthy male controls (AHI range 2-5) before and after 8 weeks of nasal continuous positive airway pressure (nCPAP). Quantitative determination of TF and vWF was performed using an enzyme-linked immunosorbent assay (ELISA) kit. The mean levels of TF (66.78±41.59 pg/ml) and vWF (189.70±69.24 IU/dl) were significantly higher in OSA patients compared with those in healthy subjects (42.83±14.18 pg/ml; and 124.48±31.43 IU/dl). Apoptotic CECs were elevated in patients with OSA and correlated strongly with TF and vWF levels (p=0.02 and p

Original languageEnglish
Pages (from-to)331-337
Number of pages7
JournalSleep and Breathing
Volume12
Issue number4
DOIs
StatePublished - 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Clinical Neurology

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    El Solh, A. A., Akinnusi, M. E., Berim, I., Peter, A. M., Paasch, L. L., & Szarpa, K. R. (2008). Hemostatic implications of endothelial cell apoptosis in obstructive sleep apnea. Sleep and Breathing, 12(4), 331-337. https://doi.org/10.1007/s11325-008-0182-x