Heparan Sulfate Core Proteins in Cell-Cell Signaling

Ken Kramer, H. Joseph Yost

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

Heparan sulfate (HS) binds numerous extracellular ligands, including cell-cell signaling molecules and their signal-transducing receptors. Ligand binding sites in HS have specific sulfation patterns; and several observations suggest that the HS sulfation pattern is the same for every HS chain that a cell synthesizes, regardless of the core protein to which it is attached. Nonetheless, virtually every Drosophila, zebrafish, Xenopus, and mouse that lacks a specific HS core protein has a mutant phenotype, even though other HS core proteins are expressed in the affected cells. Genetic manipulation of HS core protein genes is beginning to indicate that HS core proteins have functional specificities that are required during distinct stages of development.

Original languageEnglish
Pages (from-to)461-484
Number of pages24
JournalAnnual Review of Genetics
Volume37
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Heparitin Sulfate
Proteins
Ligands
Zebrafish
Xenopus
Drosophila
Binding Sites
Phenotype

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Heparan Sulfate Core Proteins in Cell-Cell Signaling. / Kramer, Ken; Yost, H. Joseph.

In: Annual Review of Genetics, Vol. 37, 2003, p. 461-484.

Research output: Contribution to journalReview article

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