Abstract
Heparan sulfate (HS) binds numerous extracellular ligands, including cell-cell signaling molecules and their signal-transducing receptors. Ligand binding sites in HS have specific sulfation patterns; and several observations suggest that the HS sulfation pattern is the same for every HS chain that a cell synthesizes, regardless of the core protein to which it is attached. Nonetheless, virtually every Drosophila, zebrafish, Xenopus, and mouse that lacks a specific HS core protein has a mutant phenotype, even though other HS core proteins are expressed in the affected cells. Genetic manipulation of HS core protein genes is beginning to indicate that HS core proteins have functional specificities that are required during distinct stages of development.
| Original language | English |
|---|---|
| Pages (from-to) | 461-484 |
| Number of pages | 24 |
| Journal | Annual Review of Genetics |
| Volume | 37 |
| DOIs | |
| State | Published - 2003 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Genetics
Cite this
Heparan Sulfate Core Proteins in Cell-Cell Signaling. / Kramer, Ken; Yost, H. Joseph.
In: Annual Review of Genetics, Vol. 37, 2003, p. 461-484.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Heparan Sulfate Core Proteins in Cell-Cell Signaling
AU - Kramer, Ken
AU - Yost, H. Joseph
PY - 2003
Y1 - 2003
N2 - Heparan sulfate (HS) binds numerous extracellular ligands, including cell-cell signaling molecules and their signal-transducing receptors. Ligand binding sites in HS have specific sulfation patterns; and several observations suggest that the HS sulfation pattern is the same for every HS chain that a cell synthesizes, regardless of the core protein to which it is attached. Nonetheless, virtually every Drosophila, zebrafish, Xenopus, and mouse that lacks a specific HS core protein has a mutant phenotype, even though other HS core proteins are expressed in the affected cells. Genetic manipulation of HS core protein genes is beginning to indicate that HS core proteins have functional specificities that are required during distinct stages of development.
AB - Heparan sulfate (HS) binds numerous extracellular ligands, including cell-cell signaling molecules and their signal-transducing receptors. Ligand binding sites in HS have specific sulfation patterns; and several observations suggest that the HS sulfation pattern is the same for every HS chain that a cell synthesizes, regardless of the core protein to which it is attached. Nonetheless, virtually every Drosophila, zebrafish, Xenopus, and mouse that lacks a specific HS core protein has a mutant phenotype, even though other HS core proteins are expressed in the affected cells. Genetic manipulation of HS core protein genes is beginning to indicate that HS core proteins have functional specificities that are required during distinct stages of development.
UR - http://www.scopus.com/inward/record.url?scp=0346785274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346785274&partnerID=8YFLogxK
U2 - 10.1146/annurev.genet.37.061103.090226
DO - 10.1146/annurev.genet.37.061103.090226
M3 - Review article
VL - 37
SP - 461
EP - 484
JO - Annual Review of Genetics
JF - Annual Review of Genetics
SN - 0066-4197
ER -