Hereditary breast cancer

Practical pursuit for clinical translation

Henry T. Lynch, Carrie Snyder, Jane Lynch

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The benefits of a skillful medical history and histologic confirmation of relevant pathology are potentially lifesaving. Appropriately directed DNA testing based on these initial steps provides an opportunity for clinical translation into a cancer prevention program targeted to family members. Unfortunately, cancer prevention strategies that are based on genetics are frequently overlooked or underestimated in the overall practical management of patients at high risk for breast cancer as well as integral cancers that constitute a hereditary breast cancer syndrome. DNA testing, particularly for BRCA1 and BRCA2 in hereditary breast-ovarian cancer syndrome and p53 in the Li-Fraumeni syndrome, and many other syndromes is commercially available for inclusion in a cancer control program and merits attention in this major public health problem. It is clear that the time and effort expended for a hereditary cancer syndrome diagnosis may significantly reduce both morbidity and mortality in breast cancer. We have found that genetic counselors can partner with the clinical physicians and make significant contributions to this labor-intensive effort.

Original languageEnglish
Pages (from-to)1723-1731
Number of pages9
JournalAnnals of Surgical Oncology
Volume19
Issue number6
DOIs
StatePublished - Jun 2012

Fingerprint

Hereditary Neoplastic Syndromes
Breast Neoplasms
Hereditary Breast and Ovarian Cancer Syndrome
Neoplasms
Li-Fraumeni Syndrome
DNA
Public Health
Pathology
Morbidity
Physicians
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Hereditary breast cancer : Practical pursuit for clinical translation. / Lynch, Henry T.; Snyder, Carrie; Lynch, Jane.

In: Annals of Surgical Oncology, Vol. 19, No. 6, 06.2012, p. 1723-1731.

Research output: Contribution to journalReview article

Lynch, Henry T. ; Snyder, Carrie ; Lynch, Jane. / Hereditary breast cancer : Practical pursuit for clinical translation. In: Annals of Surgical Oncology. 2012 ; Vol. 19, No. 6. pp. 1723-1731.
@article{8b8024264e104a97b794b36f99c51bf5,
title = "Hereditary breast cancer: Practical pursuit for clinical translation",
abstract = "The benefits of a skillful medical history and histologic confirmation of relevant pathology are potentially lifesaving. Appropriately directed DNA testing based on these initial steps provides an opportunity for clinical translation into a cancer prevention program targeted to family members. Unfortunately, cancer prevention strategies that are based on genetics are frequently overlooked or underestimated in the overall practical management of patients at high risk for breast cancer as well as integral cancers that constitute a hereditary breast cancer syndrome. DNA testing, particularly for BRCA1 and BRCA2 in hereditary breast-ovarian cancer syndrome and p53 in the Li-Fraumeni syndrome, and many other syndromes is commercially available for inclusion in a cancer control program and merits attention in this major public health problem. It is clear that the time and effort expended for a hereditary cancer syndrome diagnosis may significantly reduce both morbidity and mortality in breast cancer. We have found that genetic counselors can partner with the clinical physicians and make significant contributions to this labor-intensive effort.",
author = "Lynch, {Henry T.} and Carrie Snyder and Jane Lynch",
year = "2012",
month = "6",
doi = "10.1245/s10434-012-2256-z",
language = "English",
volume = "19",
pages = "1723--1731",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Hereditary breast cancer

T2 - Practical pursuit for clinical translation

AU - Lynch, Henry T.

AU - Snyder, Carrie

AU - Lynch, Jane

PY - 2012/6

Y1 - 2012/6

N2 - The benefits of a skillful medical history and histologic confirmation of relevant pathology are potentially lifesaving. Appropriately directed DNA testing based on these initial steps provides an opportunity for clinical translation into a cancer prevention program targeted to family members. Unfortunately, cancer prevention strategies that are based on genetics are frequently overlooked or underestimated in the overall practical management of patients at high risk for breast cancer as well as integral cancers that constitute a hereditary breast cancer syndrome. DNA testing, particularly for BRCA1 and BRCA2 in hereditary breast-ovarian cancer syndrome and p53 in the Li-Fraumeni syndrome, and many other syndromes is commercially available for inclusion in a cancer control program and merits attention in this major public health problem. It is clear that the time and effort expended for a hereditary cancer syndrome diagnosis may significantly reduce both morbidity and mortality in breast cancer. We have found that genetic counselors can partner with the clinical physicians and make significant contributions to this labor-intensive effort.

AB - The benefits of a skillful medical history and histologic confirmation of relevant pathology are potentially lifesaving. Appropriately directed DNA testing based on these initial steps provides an opportunity for clinical translation into a cancer prevention program targeted to family members. Unfortunately, cancer prevention strategies that are based on genetics are frequently overlooked or underestimated in the overall practical management of patients at high risk for breast cancer as well as integral cancers that constitute a hereditary breast cancer syndrome. DNA testing, particularly for BRCA1 and BRCA2 in hereditary breast-ovarian cancer syndrome and p53 in the Li-Fraumeni syndrome, and many other syndromes is commercially available for inclusion in a cancer control program and merits attention in this major public health problem. It is clear that the time and effort expended for a hereditary cancer syndrome diagnosis may significantly reduce both morbidity and mortality in breast cancer. We have found that genetic counselors can partner with the clinical physicians and make significant contributions to this labor-intensive effort.

UR - http://www.scopus.com/inward/record.url?scp=84865145383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865145383&partnerID=8YFLogxK

U2 - 10.1245/s10434-012-2256-z

DO - 10.1245/s10434-012-2256-z

M3 - Review article

VL - 19

SP - 1723

EP - 1731

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 6

ER -