Abstract
The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.
| Original language | English (US) |
|---|---|
| Title of host publication | The Molecular Basis of Human Cancer |
| Publisher | Springer New York |
| Pages | 335-353 |
| Number of pages | 19 |
| ISBN (Electronic) | 9781597454582 |
| ISBN (Print) | 9781934115183 |
| DOIs | |
| State | Published - Jan 1 2016 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Hereditary cancer. / Gatalica, Zoran; Ghazalpour, Anatole; Lilleberg, Stan L.; Swensen, Jeffrey; Lynch, Henry T.
The Molecular Basis of Human Cancer. Springer New York, 2016. p. 335-353.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Hereditary cancer
AU - Gatalica, Zoran
AU - Ghazalpour, Anatole
AU - Lilleberg, Stan L.
AU - Swensen, Jeffrey
AU - Lynch, Henry T.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.
AB - The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.
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UR - http://www.scopus.com/inward/citedby.url?scp=85018893047&partnerID=8YFLogxK
U2 - 10.1007/978-1-59745-458-2_22
DO - 10.1007/978-1-59745-458-2_22
M3 - Chapter
AN - SCOPUS:85018893047
SN - 9781934115183
SP - 335
EP - 353
BT - The Molecular Basis of Human Cancer
PB - Springer New York
ER -