Hereditary cancer

Zoran Gatalica; Anatole Ghazalpour; Stan L. Lilleberg; Jeffrey Swensen; Henry T. Lynch

doi:10.1007/978-1-59745-458-2_22

Hereditary cancer

Zoran Gatalica, Anatole Ghazalpour, Stan L. Lilleberg, Jeffrey Swensen, Henry T. Lynch

Department of Preventive Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.

Original language	English (US)
Title of host publication	The Molecular Basis of Human Cancer
Publisher	Springer New York
Pages	335-353
Number of pages	19
ISBN (Electronic)	9781597454582
ISBN (Print)	9781934115183
DOIs	https://doi.org/10.1007/978-1-59745-458-2_22
Publication status	Published - Jan 1 2016

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All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

Gatalica, Z., Ghazalpour, A., Lilleberg, S. L., Swensen, J., & Lynch, H. T. (2016). Hereditary cancer. In The Molecular Basis of Human Cancer (pp. 335-353). Springer New York. https://doi.org/10.1007/978-1-59745-458-2_22

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Access to Document

10.1007/978-1-59745-458-2_22