Hereditary cancer

Zoran Gatalica, Anatole Ghazalpour, Stan L. Lilleberg, Jeffrey Swensen, Henry T. Lynch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Human Cancer
PublisherSpringer New York
Pages335-353
Number of pages19
ISBN (Electronic)9781597454582
ISBN (Print)9781934115183
DOIs
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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  • Cite this

    Gatalica, Z., Ghazalpour, A., Lilleberg, S. L., Swensen, J., & Lynch, H. T. (2016). Hereditary cancer. In The Molecular Basis of Human Cancer (pp. 335-353). Springer New York. https://doi.org/10.1007/978-1-59745-458-2_22