Hereditary cancer

Zoran Gatalica, Anatole Ghazalpour, Stan L. Lilleberg, Jeffrey Swensen, Henry T. Lynch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Human Cancer
PublisherSpringer New York
Pages335-353
Number of pages19
ISBN (Electronic)9781597454582
ISBN (Print)9781934115183
DOIs
StatePublished - Jan 1 2016

Fingerprint

Neoplasms
Genes
Human Genome Project
Inborn Genetic Diseases
Documentation
Genome
Research

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Gatalica, Z., Ghazalpour, A., Lilleberg, S. L., Swensen, J., & Lynch, H. T. (2016). Hereditary cancer. In The Molecular Basis of Human Cancer (pp. 335-353). Springer New York. https://doi.org/10.1007/978-1-59745-458-2_22

Hereditary cancer. / Gatalica, Zoran; Ghazalpour, Anatole; Lilleberg, Stan L.; Swensen, Jeffrey; Lynch, Henry T.

The Molecular Basis of Human Cancer. Springer New York, 2016. p. 335-353.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gatalica, Z, Ghazalpour, A, Lilleberg, SL, Swensen, J & Lynch, HT 2016, Hereditary cancer. in The Molecular Basis of Human Cancer. Springer New York, pp. 335-353. https://doi.org/10.1007/978-1-59745-458-2_22
Gatalica Z, Ghazalpour A, Lilleberg SL, Swensen J, Lynch HT. Hereditary cancer. In The Molecular Basis of Human Cancer. Springer New York. 2016. p. 335-353 https://doi.org/10.1007/978-1-59745-458-2_22
Gatalica, Zoran ; Ghazalpour, Anatole ; Lilleberg, Stan L. ; Swensen, Jeffrey ; Lynch, Henry T. / Hereditary cancer. The Molecular Basis of Human Cancer. Springer New York, 2016. pp. 335-353
@inbook{587dd92389ba4bfea84660dcb7e71d66,
title = "Hereditary cancer",
abstract = "The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.",
author = "Zoran Gatalica and Anatole Ghazalpour and Lilleberg, {Stan L.} and Jeffrey Swensen and Lynch, {Henry T.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-1-59745-458-2_22",
language = "English (US)",
isbn = "9781934115183",
pages = "335--353",
booktitle = "The Molecular Basis of Human Cancer",
publisher = "Springer New York",
address = "United States",

}

TY - CHAP

T1 - Hereditary cancer

AU - Gatalica, Zoran

AU - Ghazalpour, Anatole

AU - Lilleberg, Stan L.

AU - Swensen, Jeffrey

AU - Lynch, Henry T.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.

AB - The first systematic documentation of a hereditary cancer family was reported over 100 years ago by Aldred Scott Warthin, M.D., Ph.D. With the continued efforts of many scientists it was finally accepted that cancer was a genetic disease. In fact, to reflect the recent revolution in cancer research and the discoveries made, it should be stated that cancer is a genomic disease, or a disease of the genome. Over the last 10-15 years, breakthroughs in the identification of many important genes have significantly improved our understanding of cancer pathogenesis. At the foundation of this discovery era was the wealth of information provided by the Human Genome Project. The intent of this chapter is to review the genes known to be associated with hereditary forms of cancer/cancer syndromes, and highlight examples of pathways in which the products of these genes interact. We also indicate where current knowledge is limited and where further investigation may be warranted.

UR - http://www.scopus.com/inward/record.url?scp=85018893047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018893047&partnerID=8YFLogxK

U2 - 10.1007/978-1-59745-458-2_22

DO - 10.1007/978-1-59745-458-2_22

M3 - Chapter

SN - 9781934115183

SP - 335

EP - 353

BT - The Molecular Basis of Human Cancer

PB - Springer New York

ER -