Hereditary cancer

Family history, diagnosis, molecular genetics, ecogenetics, and management strategies

Henry T. Lynch, Jane F. Lynch

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The translation of knowledge about hereditary breast cancer and its improved control, as well as prevention through prophylactic surgery, has been significantly accelerated through the veritable explosive discoveries in molecular genetics inclusive of BRCA1 and BRCA2 germline mutations. Needed however, among the physician community, medical genetics, and genetic counselors, is a raised level of knowledge about hereditary breast cancer syndromes. Particular attention needs to be given to their extant genotypic and phenotypic heterogeneity, their natural history, and foremost, the requirement of a sufficiently detailed family history, with knowledge as to how to interpret its significance so that hereditary cancer syndrome can be diagnosed, should it, in fact, exist in the particular family. Collectively, surveillance and management programs can then be developed for the patient and his or her high-risk relatives. We believe very firmly that this knowledge needs to be extended to the individual patient(s), first- and second-degree relatives so that they can benefit from this knowledge.

Original languageEnglish
Pages (from-to)3-17
Number of pages15
JournalBiochimie
Volume84
Issue number1
DOIs
StatePublished - 2002

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Hereditary Neoplastic Syndromes
Molecular Biology
Surgery
Breast Neoplasms
Neoplasms
Translational Medical Research
Germ-Line Mutation
Medical Genetics
Natural History
Physicians
Genetics

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Hereditary cancer : Family history, diagnosis, molecular genetics, ecogenetics, and management strategies. / Lynch, Henry T.; Lynch, Jane F.

In: Biochimie, Vol. 84, No. 1, 2002, p. 3-17.

Research output: Contribution to journalReview article

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