Abstract
The translation of knowledge about hereditary breast cancer and its improved control, as well as prevention through prophylactic surgery, has been significantly accelerated through the veritable explosive discoveries in molecular genetics inclusive of BRCA1 and BRCA2 germline mutations. Needed however, among the physician community, medical genetics, and genetic counselors, is a raised level of knowledge about hereditary breast cancer syndromes. Particular attention needs to be given to their extant genotypic and phenotypic heterogeneity, their natural history, and foremost, the requirement of a sufficiently detailed family history, with knowledge as to how to interpret its significance so that hereditary cancer syndrome can be diagnosed, should it, in fact, exist in the particular family. Collectively, surveillance and management programs can then be developed for the patient and his or her high-risk relatives. We believe very firmly that this knowledge needs to be extended to the individual patient(s), first- and second-degree relatives so that they can benefit from this knowledge.
| Original language | English |
|---|---|
| Pages (from-to) | 3-17 |
| Number of pages | 15 |
| Journal | Biochimie |
| Volume | 84 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2002 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
Cite this
Hereditary cancer : Family history, diagnosis, molecular genetics, ecogenetics, and management strategies. / Lynch, Henry T.; Lynch, Jane F.
In: Biochimie, Vol. 84, No. 1, 2002, p. 3-17.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hereditary cancer
T2 - Family history, diagnosis, molecular genetics, ecogenetics, and management strategies
AU - Lynch, Henry T.
AU - Lynch, Jane F.
PY - 2002
Y1 - 2002
N2 - The translation of knowledge about hereditary breast cancer and its improved control, as well as prevention through prophylactic surgery, has been significantly accelerated through the veritable explosive discoveries in molecular genetics inclusive of BRCA1 and BRCA2 germline mutations. Needed however, among the physician community, medical genetics, and genetic counselors, is a raised level of knowledge about hereditary breast cancer syndromes. Particular attention needs to be given to their extant genotypic and phenotypic heterogeneity, their natural history, and foremost, the requirement of a sufficiently detailed family history, with knowledge as to how to interpret its significance so that hereditary cancer syndrome can be diagnosed, should it, in fact, exist in the particular family. Collectively, surveillance and management programs can then be developed for the patient and his or her high-risk relatives. We believe very firmly that this knowledge needs to be extended to the individual patient(s), first- and second-degree relatives so that they can benefit from this knowledge.
AB - The translation of knowledge about hereditary breast cancer and its improved control, as well as prevention through prophylactic surgery, has been significantly accelerated through the veritable explosive discoveries in molecular genetics inclusive of BRCA1 and BRCA2 germline mutations. Needed however, among the physician community, medical genetics, and genetic counselors, is a raised level of knowledge about hereditary breast cancer syndromes. Particular attention needs to be given to their extant genotypic and phenotypic heterogeneity, their natural history, and foremost, the requirement of a sufficiently detailed family history, with knowledge as to how to interpret its significance so that hereditary cancer syndrome can be diagnosed, should it, in fact, exist in the particular family. Collectively, surveillance and management programs can then be developed for the patient and his or her high-risk relatives. We believe very firmly that this knowledge needs to be extended to the individual patient(s), first- and second-degree relatives so that they can benefit from this knowledge.
UR - http://www.scopus.com/inward/record.url?scp=0036256488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036256488&partnerID=8YFLogxK
U2 - 10.1016/S0300-9084(01)01363-3
DO - 10.1016/S0300-9084(01)01363-3
M3 - Review article
VL - 84
SP - 3
EP - 17
JO - Biochimie
JF - Biochimie
SN - 0300-9084
IS - 1
ER -