Hereditary diffuse gastric cancer

Association with lobular breast cancer

Kasmintan A. Schrader, Serena Masciari, Niki Boyd, Sara Wiyrick, Pardeep Kaurah, Janine Senz, Wylie Burke, Henry T. Lynch, Judy E. Garber, David G. Huntsman

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Hereditary diffuse gastric cancer (HDGC) has been shown to be caused by germline mutations in the gene CDH1 located at 16q22.1, which encodes the cell-cell adhesion molecule, E-cadherin. Not only does loss of expression of E-cadherin account for the morphologic differences between intestinal and diffuse gastric cancer (DGC) variants, but it also appears to lead to distinct cellular features which appear to be common amongst related cancers that have been seen in the syndrome. As in most hereditary cancer syndromes, multiple organ sites may be commonly affected by cancer, in HDGC, lobular carcinoma of the breast (LBC) and possibly other organ sites have been shown to be associated with the familial cancer syndrome. Given the complexity of HDGC, not only with regard to the management of the DGC risk, but also with regard to the risk for other related cancers, such as LBC, a multi-disciplinary approach is needed for the management of individuals with known CDH1 mutations.

Original languageEnglish
Pages (from-to)73-82
Number of pages10
JournalFamilial Cancer
Volume7
Issue number1
DOIs
StatePublished - 2008

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Stomach Neoplasms
Breast Neoplasms
Lobular Carcinoma
Cadherins
Neoplasms
Breast
Hereditary Neoplastic Syndromes
Germ-Line Mutation
Cell Adhesion Molecules
Mutation
Genes

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Oncology
  • Genetics(clinical)

Cite this

Schrader, K. A., Masciari, S., Boyd, N., Wiyrick, S., Kaurah, P., Senz, J., ... Huntsman, D. G. (2008). Hereditary diffuse gastric cancer: Association with lobular breast cancer. Familial Cancer, 7(1), 73-82. https://doi.org/10.1007/s10689-007-9172-6

Hereditary diffuse gastric cancer : Association with lobular breast cancer. / Schrader, Kasmintan A.; Masciari, Serena; Boyd, Niki; Wiyrick, Sara; Kaurah, Pardeep; Senz, Janine; Burke, Wylie; Lynch, Henry T.; Garber, Judy E.; Huntsman, David G.

In: Familial Cancer, Vol. 7, No. 1, 2008, p. 73-82.

Research output: Contribution to journalArticle

Schrader, KA, Masciari, S, Boyd, N, Wiyrick, S, Kaurah, P, Senz, J, Burke, W, Lynch, HT, Garber, JE & Huntsman, DG 2008, 'Hereditary diffuse gastric cancer: Association with lobular breast cancer', Familial Cancer, vol. 7, no. 1, pp. 73-82. https://doi.org/10.1007/s10689-007-9172-6
Schrader KA, Masciari S, Boyd N, Wiyrick S, Kaurah P, Senz J et al. Hereditary diffuse gastric cancer: Association with lobular breast cancer. Familial Cancer. 2008;7(1):73-82. https://doi.org/10.1007/s10689-007-9172-6
Schrader, Kasmintan A. ; Masciari, Serena ; Boyd, Niki ; Wiyrick, Sara ; Kaurah, Pardeep ; Senz, Janine ; Burke, Wylie ; Lynch, Henry T. ; Garber, Judy E. ; Huntsman, David G. / Hereditary diffuse gastric cancer : Association with lobular breast cancer. In: Familial Cancer. 2008 ; Vol. 7, No. 1. pp. 73-82.
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