Hereditary Diffuse Gastric Cancer: Prophylactic Surgical Oncology Implications

Henry T. Lynch, Edibaldo Silva, Debrah Wirtzfeld, Pamela Hebbard, Jane Lynch, David G. Huntsman

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominantly inherited syndrome attributed to mutations of the E-cadherin gene, CDH1. There is no proven effective screening for early HDGC, and symptomatic disease is almost universally fatal. The only available effective option for CDH1 carriers is prophylactic total gastrectomy, but the variable age of onset of HDGC and the reduced penetrance (about 70%) of the CDHI gene further complicate patients' decision making.

Original languageEnglish
Pages (from-to)759-778
Number of pages20
JournalSurgical Clinics of North America
Volume88
Issue number4
DOIs
StatePublished - Aug 2008

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Stomach Neoplasms
Penetrance
Cadherins
Gastrectomy
Age of Onset
Genes
Decision Making
Mutation
Surgical Oncology

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Hereditary Diffuse Gastric Cancer : Prophylactic Surgical Oncology Implications. / Lynch, Henry T.; Silva, Edibaldo; Wirtzfeld, Debrah; Hebbard, Pamela; Lynch, Jane; Huntsman, David G.

In: Surgical Clinics of North America, Vol. 88, No. 4, 08.2008, p. 759-778.

Research output: Contribution to journalReview article

Lynch, Henry T. ; Silva, Edibaldo ; Wirtzfeld, Debrah ; Hebbard, Pamela ; Lynch, Jane ; Huntsman, David G. / Hereditary Diffuse Gastric Cancer : Prophylactic Surgical Oncology Implications. In: Surgical Clinics of North America. 2008 ; Vol. 88, No. 4. pp. 759-778.
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