Hereditary nonpolyposis colon cancer

(Lynch syndrome I and II). A challenge for the clinician.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

HNPCC is common and accounts for approximately 4-6% of the total colorectal cancer burden. We have reviewed the clinical and pathology aspects of HNPCC and have made suggestions for surveillance and surgical management which would be responsive to HNPCC's natural history. Because of the proximal predominance of colonic cancer and its early age of onset, we recommend that colonoscopy be initiated by age 25 years. Once the diagnosis of colorectal cancer is established, the treatment of choice is subtotal colectomy. Attention must also be given to extracolonic sites of cancer predilection in Lynch syndrome II. A new histology finding in HNPCC is the flat adenoma. More research will be required in order to determine this lesions's status as a potential marker for HNPCC.

Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalThe Nebraska medical journal
Volume74
Issue number1
StatePublished - Jan 1989
Externally publishedYes

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Lynch Syndrome II
Hereditary Nonpolyposis Colorectal Neoplasms
Colorectal Neoplasms
Clinical Pathology
Colectomy
Colonoscopy
Natural History
Age of Onset
Adenoma
Colonic Neoplasms
Histology
Research
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Hereditary nonpolyposis colon cancer: (Lynch syndrome I and II). A challenge for the clinician.",
abstract = "HNPCC is common and accounts for approximately 4-6{\%} of the total colorectal cancer burden. We have reviewed the clinical and pathology aspects of HNPCC and have made suggestions for surveillance and surgical management which would be responsive to HNPCC's natural history. Because of the proximal predominance of colonic cancer and its early age of onset, we recommend that colonoscopy be initiated by age 25 years. Once the diagnosis of colorectal cancer is established, the treatment of choice is subtotal colectomy. Attention must also be given to extracolonic sites of cancer predilection in Lynch syndrome II. A new histology finding in HNPCC is the flat adenoma. More research will be required in order to determine this lesions's status as a potential marker for HNPCC.",
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T2 - (Lynch syndrome I and II). A challenge for the clinician.

AU - Lynch, Henry T.

AU - Boman, B.

AU - Fitzgibbons, Robert Joseph

AU - Lanspa, Stephen J.

AU - Smyrk, T. C.

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N2 - HNPCC is common and accounts for approximately 4-6% of the total colorectal cancer burden. We have reviewed the clinical and pathology aspects of HNPCC and have made suggestions for surveillance and surgical management which would be responsive to HNPCC's natural history. Because of the proximal predominance of colonic cancer and its early age of onset, we recommend that colonoscopy be initiated by age 25 years. Once the diagnosis of colorectal cancer is established, the treatment of choice is subtotal colectomy. Attention must also be given to extracolonic sites of cancer predilection in Lynch syndrome II. A new histology finding in HNPCC is the flat adenoma. More research will be required in order to determine this lesions's status as a potential marker for HNPCC.

AB - HNPCC is common and accounts for approximately 4-6% of the total colorectal cancer burden. We have reviewed the clinical and pathology aspects of HNPCC and have made suggestions for surveillance and surgical management which would be responsive to HNPCC's natural history. Because of the proximal predominance of colonic cancer and its early age of onset, we recommend that colonoscopy be initiated by age 25 years. Once the diagnosis of colorectal cancer is established, the treatment of choice is subtotal colectomy. Attention must also be given to extracolonic sites of cancer predilection in Lynch syndrome II. A new histology finding in HNPCC is the flat adenoma. More research will be required in order to determine this lesions's status as a potential marker for HNPCC.

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