Hereditary nonpolyposis colorectal cancer and colonic adenomas

Aggressive adenomas?

Henry T. Lynch, T. Smyrk, J. R. Jass

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) results from an inherited defect in one of the genes responsible for repair of errors that occur during DNA replication. Affected individuals have high risk for cancers of the colon and certain extracolonic sites. It appears that HNPCC patients form adenomas at about the same rate as the general population and there is circumstantial evidence that adenoma is the precursor to colorectal carcinoma in the syndrome. It is hypothesized that HNPCC features accelerated progression from colonic adenoma to carcinoma, a process theoretically driven by the inability to repair DNA mismatches. Evidence in support of the 'Aggressive Adenoma' in HNPCC is provided. We discuss our recommendations for colonoscopic surveillance on an annual basis for HNPCC gene-positive individuals, and for genetic counseling.

Original languageEnglish
Pages (from-to)406-410
Number of pages5
JournalSeminars in Surgical Oncology
Volume11
Issue number6
DOIs
StatePublished - 1995

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Hereditary Nonpolyposis Colorectal Neoplasms
Adenoma
DNA Mismatch Repair
Neoplasm Genes
Genetic Counseling
DNA Replication
Colonic Neoplasms
Colorectal Neoplasms
Carcinoma
Population
Genes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Hereditary nonpolyposis colorectal cancer and colonic adenomas : Aggressive adenomas? / Lynch, Henry T.; Smyrk, T.; Jass, J. R.

In: Seminars in Surgical Oncology, Vol. 11, No. 6, 1995, p. 406-410.

Research output: Contribution to journalReview article

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abstract = "Hereditary nonpolyposis colorectal cancer (HNPCC) results from an inherited defect in one of the genes responsible for repair of errors that occur during DNA replication. Affected individuals have high risk for cancers of the colon and certain extracolonic sites. It appears that HNPCC patients form adenomas at about the same rate as the general population and there is circumstantial evidence that adenoma is the precursor to colorectal carcinoma in the syndrome. It is hypothesized that HNPCC features accelerated progression from colonic adenoma to carcinoma, a process theoretically driven by the inability to repair DNA mismatches. Evidence in support of the 'Aggressive Adenoma' in HNPCC is provided. We discuss our recommendations for colonoscopic surveillance on an annual basis for HNPCC gene-positive individuals, and for genetic counseling.",
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