Hereditary nonpolyposis colorectal cancer (Lynch syndrome) in Argentina

Report from a referral hospital register

Carlos A. Vaccaro, Fernando Bonadeo, Analía V. Roverano, Paivi Peltomaki, Shashi Bala, Elise Renkonen, Maria A. Redal, Esteban Mocetti, Eduardo Mullen, Guillermo Ojea-Quintana, Mario L. Benati, Hernan Garcia Rivello, Mary B. Clark, Jane F. Lynch, Henry T. Lynch

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

PURPOSE: The first Argentine experience with epidemiologic, molecular, and genetic counseling data is reported. METHODS: We analyzed 43 families fulfilling Amsterdam criteria identified from a prospective database with data from 779 relatives. RESULTS: Eleven families (25.6 percent) presented as Lynch I, 29 (67.4 percent) as Lynch II, and 3 (7 percent) as Muir-Torre syndrome. Among the 306 affected members, 197 cases of colorectal cancer were identified (mean age at diagnosis, 52.1 (range, 21-90) years). The most frequent extracolonic tumors were gastric adenocarcinoma in males and endometrium adenocarcinoma in females. A high incidence of breast cancer was observed (16 cases among 155 females, crude rate: 11,594.20/100,000). Twenty-seven patients (8.8 percent) developed more than one tumor. These patients were younger than those with only one tumor (45 vs. 51 years; P=0.001). In 5 of 11 patients who underwent molecular sequencing, a pathologic mutation was found. A novel C deletion at 1910 nucleotide, codon 637, exon 12 of MSH2 gene was identified in a family with a strong aggregation of breast cancer with lack of MSH2 immunohistochemical staining. For 78.2 percent of counseled individuals, this session represented the first time they received information, and 73.9 percent stated that their physicians were unaware of their family background. CONCLUSIONS: Argentine families presented a high incidence of stomach cancer. The elevated incidence of breast cancer and its association with a novel hMSH2 mutation bring to consideration the inclusion of this malignancy as part of the syndrome. A lack of awareness by both physicians and persons at risk was observed.

Original languageEnglish
Pages (from-to)1604-1611
Number of pages8
JournalDiseases of the Colon and Rectum
Volume50
Issue number10
DOIs
StatePublished - Oct 2007

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Hereditary Nonpolyposis Colorectal Neoplasms
Argentina
Referral and Consultation
Breast Neoplasms
Neoplasms
Incidence
Muir-Torre Syndrome
Adenocarcinoma
Physicians
Mutation
Genetic Counseling
Endometrium
Codon
Stomach Neoplasms
Molecular Biology
Colorectal Neoplasms
Exons
Stomach
Nucleotides
Databases

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Hereditary nonpolyposis colorectal cancer (Lynch syndrome) in Argentina : Report from a referral hospital register. / Vaccaro, Carlos A.; Bonadeo, Fernando; Roverano, Analía V.; Peltomaki, Paivi; Bala, Shashi; Renkonen, Elise; Redal, Maria A.; Mocetti, Esteban; Mullen, Eduardo; Ojea-Quintana, Guillermo; Benati, Mario L.; Rivello, Hernan Garcia; Clark, Mary B.; Lynch, Jane F.; Lynch, Henry T.

In: Diseases of the Colon and Rectum, Vol. 50, No. 10, 10.2007, p. 1604-1611.

Research output: Contribution to journalArticle

Vaccaro, CA, Bonadeo, F, Roverano, AV, Peltomaki, P, Bala, S, Renkonen, E, Redal, MA, Mocetti, E, Mullen, E, Ojea-Quintana, G, Benati, ML, Rivello, HG, Clark, MB, Lynch, JF & Lynch, HT 2007, 'Hereditary nonpolyposis colorectal cancer (Lynch syndrome) in Argentina: Report from a referral hospital register', Diseases of the Colon and Rectum, vol. 50, no. 10, pp. 1604-1611. https://doi.org/10.1007/s10350-007-9037-y
Vaccaro, Carlos A. ; Bonadeo, Fernando ; Roverano, Analía V. ; Peltomaki, Paivi ; Bala, Shashi ; Renkonen, Elise ; Redal, Maria A. ; Mocetti, Esteban ; Mullen, Eduardo ; Ojea-Quintana, Guillermo ; Benati, Mario L. ; Rivello, Hernan Garcia ; Clark, Mary B. ; Lynch, Jane F. ; Lynch, Henry T. / Hereditary nonpolyposis colorectal cancer (Lynch syndrome) in Argentina : Report from a referral hospital register. In: Diseases of the Colon and Rectum. 2007 ; Vol. 50, No. 10. pp. 1604-1611.
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abstract = "PURPOSE: The first Argentine experience with epidemiologic, molecular, and genetic counseling data is reported. METHODS: We analyzed 43 families fulfilling Amsterdam criteria identified from a prospective database with data from 779 relatives. RESULTS: Eleven families (25.6 percent) presented as Lynch I, 29 (67.4 percent) as Lynch II, and 3 (7 percent) as Muir-Torre syndrome. Among the 306 affected members, 197 cases of colorectal cancer were identified (mean age at diagnosis, 52.1 (range, 21-90) years). The most frequent extracolonic tumors were gastric adenocarcinoma in males and endometrium adenocarcinoma in females. A high incidence of breast cancer was observed (16 cases among 155 females, crude rate: 11,594.20/100,000). Twenty-seven patients (8.8 percent) developed more than one tumor. These patients were younger than those with only one tumor (45 vs. 51 years; P=0.001). In 5 of 11 patients who underwent molecular sequencing, a pathologic mutation was found. A novel C deletion at 1910 nucleotide, codon 637, exon 12 of MSH2 gene was identified in a family with a strong aggregation of breast cancer with lack of MSH2 immunohistochemical staining. For 78.2 percent of counseled individuals, this session represented the first time they received information, and 73.9 percent stated that their physicians were unaware of their family background. CONCLUSIONS: Argentine families presented a high incidence of stomach cancer. The elevated incidence of breast cancer and its association with a novel hMSH2 mutation bring to consideration the inclusion of this malignancy as part of the syndrome. A lack of awareness by both physicians and persons at risk was observed.",
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T1 - Hereditary nonpolyposis colorectal cancer (Lynch syndrome) in Argentina

T2 - Report from a referral hospital register

AU - Vaccaro, Carlos A.

AU - Bonadeo, Fernando

AU - Roverano, Analía V.

AU - Peltomaki, Paivi

AU - Bala, Shashi

AU - Renkonen, Elise

AU - Redal, Maria A.

AU - Mocetti, Esteban

AU - Mullen, Eduardo

AU - Ojea-Quintana, Guillermo

AU - Benati, Mario L.

AU - Rivello, Hernan Garcia

AU - Clark, Mary B.

AU - Lynch, Jane F.

AU - Lynch, Henry T.

PY - 2007/10

Y1 - 2007/10

N2 - PURPOSE: The first Argentine experience with epidemiologic, molecular, and genetic counseling data is reported. METHODS: We analyzed 43 families fulfilling Amsterdam criteria identified from a prospective database with data from 779 relatives. RESULTS: Eleven families (25.6 percent) presented as Lynch I, 29 (67.4 percent) as Lynch II, and 3 (7 percent) as Muir-Torre syndrome. Among the 306 affected members, 197 cases of colorectal cancer were identified (mean age at diagnosis, 52.1 (range, 21-90) years). The most frequent extracolonic tumors were gastric adenocarcinoma in males and endometrium adenocarcinoma in females. A high incidence of breast cancer was observed (16 cases among 155 females, crude rate: 11,594.20/100,000). Twenty-seven patients (8.8 percent) developed more than one tumor. These patients were younger than those with only one tumor (45 vs. 51 years; P=0.001). In 5 of 11 patients who underwent molecular sequencing, a pathologic mutation was found. A novel C deletion at 1910 nucleotide, codon 637, exon 12 of MSH2 gene was identified in a family with a strong aggregation of breast cancer with lack of MSH2 immunohistochemical staining. For 78.2 percent of counseled individuals, this session represented the first time they received information, and 73.9 percent stated that their physicians were unaware of their family background. CONCLUSIONS: Argentine families presented a high incidence of stomach cancer. The elevated incidence of breast cancer and its association with a novel hMSH2 mutation bring to consideration the inclusion of this malignancy as part of the syndrome. A lack of awareness by both physicians and persons at risk was observed.

AB - PURPOSE: The first Argentine experience with epidemiologic, molecular, and genetic counseling data is reported. METHODS: We analyzed 43 families fulfilling Amsterdam criteria identified from a prospective database with data from 779 relatives. RESULTS: Eleven families (25.6 percent) presented as Lynch I, 29 (67.4 percent) as Lynch II, and 3 (7 percent) as Muir-Torre syndrome. Among the 306 affected members, 197 cases of colorectal cancer were identified (mean age at diagnosis, 52.1 (range, 21-90) years). The most frequent extracolonic tumors were gastric adenocarcinoma in males and endometrium adenocarcinoma in females. A high incidence of breast cancer was observed (16 cases among 155 females, crude rate: 11,594.20/100,000). Twenty-seven patients (8.8 percent) developed more than one tumor. These patients were younger than those with only one tumor (45 vs. 51 years; P=0.001). In 5 of 11 patients who underwent molecular sequencing, a pathologic mutation was found. A novel C deletion at 1910 nucleotide, codon 637, exon 12 of MSH2 gene was identified in a family with a strong aggregation of breast cancer with lack of MSH2 immunohistochemical staining. For 78.2 percent of counseled individuals, this session represented the first time they received information, and 73.9 percent stated that their physicians were unaware of their family background. CONCLUSIONS: Argentine families presented a high incidence of stomach cancer. The elevated incidence of breast cancer and its association with a novel hMSH2 mutation bring to consideration the inclusion of this malignancy as part of the syndrome. A lack of awareness by both physicians and persons at risk was observed.

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