Abstract
We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-28 |
| Number of pages | 10 |
| Journal | Medical Hypotheses |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1985 |
All Science Journal Classification (ASJC) codes
- Medicine(all)
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Lynch, H. T., & Lynch, J. F. (1985). Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): A common genotype linked to oncogenes? Medical Hypotheses, 18(1), 19-28. https://doi.org/10.1016/0306-9877(85)90115-X