Abstract
We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.
| Original language | English |
|---|---|
| Pages (from-to) | 19-28 |
| Number of pages | 10 |
| Journal | Medical Hypotheses |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1985 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Medicine(all)
- Drug Discovery
Cite this
Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II) : A common genotype linked to oncogenes? / Lynch, Henry T.; Lynch, Jane F.
In: Medical Hypotheses, Vol. 18, No. 1, 1985, p. 19-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II)
T2 - A common genotype linked to oncogenes?
AU - Lynch, Henry T.
AU - Lynch, Jane F.
PY - 1985
Y1 - 1985
N2 - We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.
AB - We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022261588&partnerID=8YFLogxK
U2 - 10.1016/0306-9877(85)90115-X
DO - 10.1016/0306-9877(85)90115-X
M3 - Article
C2 - 4069033
AN - SCOPUS:0022261588
VL - 18
SP - 19
EP - 28
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 1
ER -