Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II)

A common genotype linked to oncogenes?

Henry T. Lynch, Jane F. Lynch

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.

Original languageEnglish
Pages (from-to)19-28
Number of pages10
JournalMedical Hypotheses
Volume18
Issue number1
DOIs
StatePublished - 1985

Fingerprint

Lynch Syndrome II
Hereditary Nonpolyposis Colorectal Neoplasms
Oncogenes
Mucous Membrane
Genotype
Polyps
Colonic Neoplasms
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II) : A common genotype linked to oncogenes? / Lynch, Henry T.; Lynch, Jane F.

In: Medical Hypotheses, Vol. 18, No. 1, 1985, p. 19-28.

Research output: Contribution to journalArticle

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