Abstract
We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.
Original language | English (US) |
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Pages (from-to) | 19-28 |
Number of pages | 10 |
Journal | Medical Hypotheses |
Volume | 18 |
Issue number | 1 |
DOIs | |
State | Published - Sep 1985 |
All Science Journal Classification (ASJC) codes
- Medicine(all)