Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): A common genotype linked to oncogenes?

Henry T. Lynch; Jane F. Lynch

doi:10.1016/0306-9877(85)90115-X

Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): A common genotype linked to oncogenes?

Henry T. Lynch, Jane F. Lynch

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.

Original language	English (US)
Pages (from-to)	19-28
Number of pages	10
Journal	Medical Hypotheses
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/0306-9877(85)90115-X
State	Published - Sep 1985

All Science Journal Classification (ASJC) codes

Medicine(all)

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title = "Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): A common genotype linked to oncogenes?",

abstract = "We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.",

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AB - We hypothesize that: 1) hereditary nonpolyposis colorectal cancer (HNP CC) accounts for a significant proportion of the colon cancer burden; 2) the premalignant colonic mucosa in HNP CC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, 3) study of HNP CC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.

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Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): A common genotype linked to oncogenes?

Abstract

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