Hereditary ovarian cancer. Heterogeneity in age at diagnosis

Henry T. Lynch, P. Watson, C. Bewtra, T. A. Conway, C. Read Hippee, P. Kaur, J. F. Lynch, B. A J Ponder

Research output: Contribution to journalArticle

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Abstract

An unknown fraction of the ovarian cancer burden occurs in women with a family history indicative of a putative autosomal dominantly inherited cancer susceptibility syndrome. The results from a five-generation, extended, hereditary breast-ovarian cancer kindred are described 10 years after it was initially as certained. Significantly more cancers were observed in high-risk family members during this decade than were expected (P <0.001). The age of ovarian cancer diagnosis was studied in additional ovarian cancer-prone families of three types: site-specific ovarian cancer syndrome, the breast-ovarian cancer syndrome, and Lynch syndrome II. The age of onset in each of the three sets was significantly (P <0.001) earlier than the general population mean of 59, and there were significant differences in the age of onset (P = 0.050) among these three cohorts. Ovarian cancer histology was similar to that of patients with negative family histories. There may be clinically significant heterogeneity in the age at diagnosis of ovarian cancer among these ovarian cancer-prone syndromes. This has important implications for understanding its natural history and targeting surveillance management strategies.

Original languageEnglish
Pages (from-to)1460-1466
Number of pages7
JournalCancer
Volume67
Issue number5
StatePublished - 1991

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Ovarian Neoplasms
Breast Neoplasms
Age of Onset
Lynch Syndrome II
Natural History
Neoplasms
Histology
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Watson, P., Bewtra, C., Conway, T. A., Read Hippee, C., Kaur, P., ... Ponder, B. A. J. (1991). Hereditary ovarian cancer. Heterogeneity in age at diagnosis. Cancer, 67(5), 1460-1466.

Hereditary ovarian cancer. Heterogeneity in age at diagnosis. / Lynch, Henry T.; Watson, P.; Bewtra, C.; Conway, T. A.; Read Hippee, C.; Kaur, P.; Lynch, J. F.; Ponder, B. A J.

In: Cancer, Vol. 67, No. 5, 1991, p. 1460-1466.

Research output: Contribution to journalArticle

Lynch, HT, Watson, P, Bewtra, C, Conway, TA, Read Hippee, C, Kaur, P, Lynch, JF & Ponder, BAJ 1991, 'Hereditary ovarian cancer. Heterogeneity in age at diagnosis', Cancer, vol. 67, no. 5, pp. 1460-1466.
Lynch HT, Watson P, Bewtra C, Conway TA, Read Hippee C, Kaur P et al. Hereditary ovarian cancer. Heterogeneity in age at diagnosis. Cancer. 1991;67(5):1460-1466.
Lynch, Henry T. ; Watson, P. ; Bewtra, C. ; Conway, T. A. ; Read Hippee, C. ; Kaur, P. ; Lynch, J. F. ; Ponder, B. A J. / Hereditary ovarian cancer. Heterogeneity in age at diagnosis. In: Cancer. 1991 ; Vol. 67, No. 5. pp. 1460-1466.
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